灯心草属菖蒲中的菲类化合物具有抗焦虑和镇静活性。
Phenanthrenes from Juncus effusus with anxiolytic and sedative activities.
机构信息
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, P.R. China.
出版信息
Nat Prod Res. 2012;26(13):1234-9. doi: 10.1080/14786419.2011.561491. Epub 2011 Oct 24.
Eight phenanthrenes, 7-carboxy-2-hydroxy-1-methyl-5-vinyl-phenanthrene (1); 2,7-dihydroxy-1-methyl-5-aldehyde-9,10-dihydrophenanthrene (2); dehydroeffusol (3); dehydrojuncusol (4); 7-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (5); 8-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene (6); effusol (7) and juncusol (8), were isolated from the aerial part of Juncus effusus. Compounds 1 and 2 were identified as new constituents. Compounds 7 and 8 showed anxiolytic and sedative activities.
从灯心草（Juncus effusus）的地上部分分离得到了 8 个菲类化合物，分别为：7-羧基-2-羟基-1-甲基-5-乙烯基菲（1）；2，7-二羟基-1-甲基-5-醛基-9，10-二氢菲（2）；脱氢菖蒲烯醇（3）；脱氢筋骨草醇（4）；7-羧基-2-羟基-1-甲基-5-乙烯基-9，10-二氢菲（5）；8-羧基-2-羟基-1-甲基-5-乙烯基-9，10-二氢菲（6）；菖蒲烯醇（7）和筋骨草醇（8）。其中，化合物 1 和 2 被鉴定为新的成分。化合物 7 和 8 表现出抗焦虑和镇静活性。
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