Schaeffer A J, Darras F S
Department of Urology, Northwestern University Medical School, Chicago, Illinois.
J Urol. 1990 Sep;144(3):690-3. doi: 10.1016/s0022-5347(17)39556-3.
We treated 15 men who had chronic bacterial prostatitis refractory to trimethoprim-sulfamethoxazole and/or carbenicillin with 400 mg. norfloxacin twice daily for 28 days. All pathogens were susceptible to norfloxacin and absent in prostatic fluid cultures obtained during therapy. One patient had negative post-therapy prostatic fluid cultures but was lost to followup at 1 month. Of the 14 patients followed for at least 6 months 9 (64%) were cured of the original infection, including 6 who have remained uninfected and have had negative prostatic secretion and urine cultures for at least 2 years (1), 1 year (2) or 6 months (3). In 3 patients urinary tract infections recurred with new pathogens at 6, 560 and 820 days after post-therapy negative prostatic fluid cultures. Bacterial prostatitis with the original pathogen recurred in 5 patients within 2 months of completing therapy. The bacteria remained susceptible to norfloxacin but could not be eradicated with 30 to 90 days of additional norfloxacin therapy. Cures were achieved in 9 of 12 patients with Escherichia coli, none of 2 with Pseudomonas prostatitis and 3 of 5 with prostatic calculi. No patient experienced significant adverse effects. The data suggest that norfloxacin is effective and safe for the treatment of refractory chronic bacterial prostatitis.
我们对15名患有慢性细菌性前列腺炎的男性患者进行了治疗，这些患者对甲氧苄啶-磺胺甲恶唑和/或羧苄青霉素治疗无效，给予其每日两次400毫克诺氟沙星，疗程为28天。所有病原体对诺氟沙星敏感，且在治疗期间获取的前列腺液培养中未检出。1例患者治疗后前列腺液培养呈阴性，但在1个月时失访。在14例至少随访6个月的患者中，9例（64%）原感染得以治愈，其中6例持续未感染，前列腺分泌物及尿液培养阴性至少达2年（1例）、1年（2例）或6个月（3例）。3例患者在治疗后前列腺液培养阴性后的6天、560天和820天出现了由新病原体引起的尿路感染复发。5例患者在完成治疗后的2个月内，原病原体导致的细菌性前列腺炎复发。这些细菌对诺氟沙星仍敏感，但再给予30至90天的诺氟沙星治疗无法将其根除。12例大肠杆菌感染患者中有9例治愈，2例假单胞菌性前列腺炎患者均未治愈，5例前列腺结石患者中有3例治愈。无一例患者出现明显不良反应。数据表明，诺氟沙星治疗难治性慢性细菌性前列腺炎有效且安全。
