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两个遗传位点控制近交系小鼠求偶超声叫声的音节序列。

Two genetic loci control syllable sequences of ultrasonic courtship vocalizations in inbred mice.

机构信息

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea.

出版信息

BMC Neurosci. 2011 Oct 21;12:104. doi: 10.1186/1471-2202-12-104.

DOI:10.1186/1471-2202-12-104
PMID:22018021
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3215659/
Abstract

BACKGROUND

The ultrasonic vocalizations (USV) of courting male mice are known to possess a phonetic structure with a complex combination of several syllables. The genetic mechanisms underlying the syllable sequence organization were investigated.

RESULTS

This study compared syllable sequence organization in two inbred strains of mice, 129S4/SvJae (129) and C57BL6J (B6), and demonstrated that they possessed two mutually exclusive phenotypes. The 129S4/SvJae (129) strain frequently exhibited a "chevron-wave" USV pattern, which was characterized by the repetition of chevron-type syllables. The C57BL/6J strain produced a "staccato" USV pattern, which was characterized by the repetition of short-type syllables. An F1 strain obtained by crossing the 129S4/SvJae and C57BL/6J strains produced only the staccato phenotype. The chevron-wave and staccato phenotypes reappeared in the F2 generations, following the Mendelian law of independent assortment.

CONCLUSIONS

These results suggest that two genetic loci control the organization of syllable sequences. These loci were occupied by the staccato and chevron-wave alleles in the B6 and 129 mouse strains, respectively. Recombination of these alleles might lead to the diversity of USV patterns produced by mice.

摘要

背景

求爱雄性小鼠的超声发声（USV）具有复杂的多音节组合的语音结构。本研究旨在探讨这种音节序列组织的遗传机制。

结果

本研究比较了两种近交系小鼠（129S4/SvJae [129] 和 C57BL6J [B6]）的音节序列组织，结果表明它们具有两种互斥的表型。129S4/SvJae（129）品系经常表现出“人字形波”USV 模式，其特征是重复人字形音节。C57BL/6J 品系产生“断奏”USV 模式，其特征是重复短音节。通过杂交 129S4/SvJae 和 C57BL/6J 品系获得的 F1 品系仅产生断奏表型。人字波和断奏表型在遵循孟德尔独立分配定律的 F2 代中再次出现。

结论

这些结果表明，两个遗传位点控制着音节序列的组织。这两个位点分别被 B6 和 129 小鼠品系中的断奏和人字形波等位基因占据。这些等位基因的重组可能导致小鼠产生的 USV 模式的多样性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/c5169a4e9ea1/1471-2202-12-104-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/036bfb7ea8c9/1471-2202-12-104-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/db1530b0a492/1471-2202-12-104-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/44ff36e6737d/1471-2202-12-104-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/c5169a4e9ea1/1471-2202-12-104-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/036bfb7ea8c9/1471-2202-12-104-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/db1530b0a492/1471-2202-12-104-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/44ff36e6737d/1471-2202-12-104-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f295/3215659/c5169a4e9ea1/1471-2202-12-104-4.jpg

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Unusual repertoire of vocalizations in adult BTBR T+tf/J mice during three types of social encounters.成年 BTBR T+tf/J 小鼠在三种社交接触中表现出不同寻常的发声 repertoire。
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