Rubicz Rohina, Leach Charles T, Kraig Ellen, Dhurandhar Nikhil V, Grubbs Barry, Blangero John, Yolken Robert, Göring Harald Hh
Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX 78245-0549, USA.
BMC Res Notes. 2011 Oct 21;4:433. doi: 10.1186/1756-0500-4-433.
Infection risks vary among individuals and between populations. Here we present information on the seroprevalence of 13 common infectious agents in a San Antonio-based sample of Mexican Americans. Mexican Americans represent the largest and most rapidly growing minority population in the U.S., and they are also considered a health disparities population.
We analyzed 1227 individuals for antibody titer to Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, cytomegalovirus, Epstein-Barr virus, herpes simplex virus-1, herpes simplex virus-2 (HSV-2), human herpesvirus-6 (HHV-6), varicella zoster virus (VZV), adenovirus-36, hepatitis A virus, and influenza A and B. Seroprevalence was examined as a function of sex, age, household income, and education.
Seroprevalence estimates ranged from 9% for T. gondii to 92% for VZV, and were similar in both sexes except for HSV-2, which was more prevalent in women. Many pathogens exhibited a significant seroprevalence change over the examined age range (15-94 years), with 7 pathogens increasing and HHV-6 decreasing with age. Socioeconomic status significantly correlated with serostatus for some pathogens.
Our findings demonstrate substantial seroprevalence rates of these common infections in this sample of Mexican Americans from San Antonio, Texas that suffers from high rates of chronic diseases including obesity and type-2 diabetes.
感染风险在个体之间以及人群之间存在差异。在此，我们呈现了在一个以圣安东尼奥为基地的墨西哥裔美国人样本中13种常见感染病原体的血清流行率信息。墨西哥裔美国人是美国最大且增长最快的少数族裔群体，他们也被视为存在健康差异的人群。
我们分析了1227名个体针对肺炎衣原体、幽门螺杆菌、弓形虫、巨细胞病毒、爱泼斯坦 - 巴尔病毒、单纯疱疹病毒1型、单纯疱疹病毒2型（HSV - 2）、人类疱疹病毒6型（HHV - 6）、水痘带状疱疹病毒（VZV）、腺病毒36型、甲型肝炎病毒以及甲型和乙型流感病毒的抗体滴度。血清流行率作为性别、年龄、家庭收入和教育程度的函数进行了研究。
血清流行率估计值范围从弓形虫的9%到水痘带状疱疹病毒的92%，除了HSV - 2在女性中更普遍外，两性之间相似。许多病原体在所研究的年龄范围（15 - 94岁）内呈现出显著的血清流行率变化，7种病原体随年龄增加，HHV - 6随年龄降低。社会经济地位与某些病原体的血清状态显著相关。
我们的研究结果表明在来自德克萨斯州圣安东尼奥的这个墨西哥裔美国人样本中，这些常见感染的血清流行率相当高，该样本患有包括肥胖症和2型糖尿病在内的高慢性病发病率。
