Department of Respiratory Diseases Research, Naval Health Research Center, San Diego, CA 92186-5122, USA.
Int J Obes (Lond). 2010 Feb;34(2):302-8. doi: 10.1038/ijo.2009.224. Epub 2009 Nov 10.
Although several studies have shown a positive association between evidence of anti-adenovirus 36 (Ad-36) antibodies (Ad-36 exposure) and (1) obesity and (2) serum cholesterol in animals, there is limited research demonstrating this association in humans. There is also limited research on transmission, presentation and demographics of Ad-36 infection.
(1) Body mass (body mass index (BMI)), (2) fasting serum cholesterol and triglyceride levels and (3) demographic characteristics were compared between Ad-36 seropositive and seronegative groups. The majority of subjects were matched as cases versus controls on a number of demographic variables.
A total of 150 obese and 150 lean active-duty military personnel were studied.
Subjects completed a questionnaire regarding demographic and behavioral characteristics. Subject serum samples were tested by serum neutralization assay for the presence of anti-Ad-36 antibodies.
In all, 34% of obese and 39% of lean subjects had Ad-36 exposure, an insignificant difference. Serum cholesterol and triglyceride levels were significantly higher among the obese subjects than among the lean, but there were no associations between serum cholesterol and triglyceride levels and Ad-36 exposure. Positive associations were found between Ad-36 exposure and age, race and gender.
The study stands in contrast to previous work that has shown a positive relationship between Ad-36 exposure and (1) obesity, and (2) levels of serum cholesterol and triglycerides. In this study there was no association in either case. Unanticipated relationships between Ad-36 exposure and age, race and gender were found, and this is the first time that such a link between Ad-36 exposure and demographics has been found.
尽管有几项研究表明抗腺病毒 36（Ad-36）抗体（Ad-36 暴露）与（1）肥胖和（2）血清胆固醇之间存在正相关，但在人类中证明这种相关性的研究有限。关于 Ad-36 感染的传播、表现和人群特征的研究也很有限。
（1）体重（体重指数（BMI））、（2）空腹血清胆固醇和甘油三酯水平以及（3）人口统计学特征在 Ad-36 血清阳性和血清阴性组之间进行比较。大多数受试者在许多人口统计学变量上与对照组进行病例对照匹配。
共研究了 150 名肥胖和 150 名瘦的现役军人。
受试者完成了一份关于人口统计学和行为特征的问卷。通过血清中和试验检测受试者血清样本中是否存在抗 Ad-36 抗体。
肥胖组和瘦组分别有 34%和 39%的受试者 Ad-36 暴露，差异无统计学意义。肥胖组的血清胆固醇和甘油三酯水平明显高于瘦组，但血清胆固醇和甘油三酯水平与 Ad-36 暴露之间无关联。Ad-36 暴露与年龄、种族和性别呈正相关。
与之前的研究结果相反，该研究表明 Ad-36 暴露与（1）肥胖和（2）血清胆固醇和甘油三酯水平之间存在正相关。在本研究中，两种情况均无关联。发现 Ad-36 暴露与年龄、种族和性别之间存在意外关联，这是首次发现 Ad-36 暴露与人口统计学之间存在这种关联。
