喉鳞状细胞癌的发病率和患者死亡率与ABO血型有关吗？一项回顾性研究。
Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study.
作者信息
Adam S I, Wilson K M, Overholser S M, Khabbaz E, Moreno K, Patil Y J
机构信息
Department of Otolaryngology-Head and Neck Surgery, Brain Tumor Center, University of Cincinnati Neuroscience Institute and University of Cincinnati College of Medicine, Ohio, USA.
出版信息
J Laryngol Otol. 2012 Feb;126(2):180-4. doi: 10.1017/S0022215111002507. Epub 2011 Oct 10.
OBJECTIVE
Few studies have examined the association between ABO blood grouping and head and neck cancer. This retrospective review examined the association between blood group and laryngeal cancer incidence and patient mortality.
METHODS
Of 271 patients treated for squamous cell laryngeal carcinoma (1997-2002), 143 patients with supraglottic, glottic and subglottic tumours were included; 128 patients were excluded. The blood group characteristics of patients and healthy blood donors were compared.
RESULTS
There was no significant correlation between blood type and laryngeal carcinoma incidence or mortality. Type A blood was commoner in African Americans with laryngeal cancer than Caucasian patients, but not significantly so. As expected, five-year survival rates were lower in patients with more advanced stage cancer (p < 0.0001).
CONCLUSION
Although our findings show no association between blood group and five-year survival, these results are inconclusive, and warrant further study of the association between blood type and laryngeal (and other) head and neck cancers.
目的
很少有研究探讨ABO血型与头颈癌之间的关联。本回顾性研究调查了血型与喉癌发病率及患者死亡率之间的关联。
方法
在271例接受鳞状细胞喉癌治疗的患者（1997 - 2002年）中，纳入143例声门上、声门和声门下肿瘤患者；排除128例患者。比较了患者与健康献血者的血型特征。
结果
血型与喉癌发病率或死亡率之间无显著相关性。患有喉癌的非裔美国人中A型血比白人患者更常见，但差异无统计学意义。正如预期的那样，癌症分期较晚的患者五年生存率较低（p < 0.0001）。
结论
虽然我们的研究结果显示血型与五年生存率之间无关联，但这些结果尚无定论，有必要进一步研究血型与喉癌（及其他）头颈癌之间的关联。
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