肛管鳞状细胞癌的放化疗：病例报告

Chemoradiation for anal squamous cell carcinoma: case report.

作者信息

Fiengo L, Ekci B, Tellan G, Marandola M, Redler A

机构信息

Department of Surgery Sciences, Sapienza, University, Rome, Italy.

出版信息

G Chir. 2011 Aug-Sep;32(8-9):365-7.

PMID:22018257

Abstract

INTRODUCTION

Anal squamous cell carcinoma is rare and seems to be associated with chronic inflammatory conditions, infections and immunosuppression. Their incidence has been arising since the last 25 years. Compared to adenocarcinoma of the rectum and squamous cell cancer of the anal canal, squamous cell carcinoma is a distinct entity with a different etiology, pathogenesis, prognosis and requires a different therapeutic approach. Even if surgery remains the main therapeutic option, recent advances have made chemoradiation a valuable therapeutic addition. This case discuss the efficacy of chemoradiation wich can prevent complications and can improve the quality of life.

CASE REPORT

A 63-year-old woman presented with history of bloody stool for the last past month. The colonoscopy showed a 2 cm circular lesion on the posterior wall of the anal canal. Biopsy was positive for squamous cell carcinoma and afterwards the patient underwent chemoradiation. At 1 year of follow-up the patient is disease free, with a good sphincter control and had no late complications.

CONCLUSION

Since the first studies in 1974, chemoradiation seems to be a good option for most patients with squamous cell carcinoma avoiding surgery.

摘要

引言

肛管鳞状细胞癌较为罕见，似乎与慢性炎症、感染及免疫抑制有关。在过去25年中，其发病率一直在上升。与直肠腺癌和肛管鳞状细胞癌相比，肛管鳞状细胞癌是一种具有不同病因、发病机制和预后的独特实体，需要不同的治疗方法。即使手术仍然是主要的治疗选择，但最近的进展使放化疗成为一种有价值的辅助治疗方法。本病例讨论了放化疗的疗效，其可预防并发症并改善生活质量。