Department of Haematology, Imperial College and Hammersmith Hospital, London, UK.
Leuk Res. 2012 Mar;36(3):271-4. doi: 10.1016/j.leukres.2011.09.025. Epub 2011 Oct 20.
Imatinib should be avoided in women planning to become pregnant or during pregnancy, due to a higher risk of congenital malformations. However, it is not known whether imatinib affects future potential for fertility. Here we analysed ovaries and testes from adult mice receiving imatinib, focusing on testicular and ovarian functions. Seven male and 7 female mice were orally treated with 150 mg/kg body weight/day imatinib for two months. No effects on folliculogenesis or spermatogenesis could be observed postmortem by histological examinations, suggesting that, at least in two mouse models of imatinib treatment this tyrosine kinase inhibitor does not reduce fertility.
由于存在先天畸形的更高风险，伊马替尼应避免在计划怀孕或怀孕期间的女性中使用。然而，尚不清楚伊马替尼是否会影响未来的生育能力。在这里，我们分析了接受伊马替尼治疗的成年小鼠的卵巢和睾丸，重点研究了睾丸和卵巢功能。7 只雄性和 7 只雌性小鼠经口给予 150mg/kg 体重/天的伊马替尼治疗两个月。通过组织学检查在死后未观察到对卵泡发生或精子发生的影响，这表明，至少在两种伊马替尼治疗的小鼠模型中，这种酪氨酸激酶抑制剂不会降低生育能力。
