Department of Surgery, University of Kansas School of Medicine-Wichita, Wichita, KS, USA.
Am J Surg. 2011 Dec;202(6):707-11; discussion 711-2. doi: 10.1016/j.amjsurg.2011.06.040. Epub 2011 Oct 21.
Topical anesthetics have been used in various procedures. The purpose of this study was to evaluate efficacy of lidocaine/prilocaine cream in decreasing the pain of injection for sentinel lymph node biopsy.
A prospective, randomized, placebo-controlled study was conducted on female breast cancer patients undergoing periareolar injection for sentinel lymph node isolation. Subjects applied lidocaine/prilocaine cream or a placebo cream before injection and completed a survey postoperatively.
Twenty treatment and 19 control patients were studied. There was a trend for control subjects to indicate that the injection was "painful" or "extremely painful" more often than treatment subjects (52.6% vs 25.0%, respectively, P = .074). The treatment group was more likely to recommend the cream to other cancer patients (70.0% vs 42.1%), with a trend toward significance (P = .076).
This study showed no statistically significant reduction in pain scores in subjects receiving the topical anesthetic. Further studies targeting patients with low pain tolerance may prove more effective.
局部麻醉剂已被用于各种程序中。本研究的目的是评估利多卡因/丙胺卡因乳膏在减少前哨淋巴结活检注射疼痛中的效果。
对接受乳晕周围注射以分离前哨淋巴结的女性乳腺癌患者进行了一项前瞻性、随机、安慰剂对照研究。受试者在注射前应用利多卡因/丙胺卡因乳膏或安慰剂乳膏，并在术后完成一项调查。
研究了 20 例治疗组和 19 例对照组患者。与治疗组相比，对照组更倾向于表示注射“疼痛”或“非常疼痛”（分别为 52.6%和 25.0%，P =.074）。治疗组更倾向于向其他癌症患者推荐该乳膏（70.0%比 42.1%），具有显著趋势（P =.076）。
本研究显示，接受局部麻醉的受试者的疼痛评分没有统计学上的显著降低。针对疼痛耐受度低的患者的进一步研究可能会更有效。
