人肠道病毒的分子流行病学、基因组特征和重组事件。

Molecular epidemiology, genome characterization, and recombination event of human parechovirus.

机构信息

Center of Excellence in Clinical Virology, Department of Pediatrics, Chulalongkorng University, Bangkok, Thailand.

出版信息

Virology. 2011 Dec 20;421(2):159-66. doi: 10.1016/j.virol.2011.09.021. Epub 2011 Oct 21.

DOI:10.1016/j.virol.2011.09.021

PMID:22018784

Abstract

Human Parechovirus (HPeV), a member of the Picornaviridae family, is an infectious agent mostly affecting children. There are 16 recognized genotypes which have globally spread. This study incorporated a total of 2957 nasopharyngeal (NP) swab and 759 fecal samples that were collected from different parts of Thailand. The NP of HPeV was detected in 0.4% of NP swab and 6.1% of fecal samples. The majority of HPeV infections occur in infants below the age of 2 years, while infections were detected in children above the age of 10 years as well. Various genotypes comprising 1A, 1B, 2, 3, 4, 5, 6, 10 and 14 have been characterized. This study revealed recombination events in 16 samples in which HPeV1B was shown as the highest frequency. In conclusion, HPeV can be detected in both the respiratory and GI tract. Moreover, HPeV which circulates in Thailand is highly diverse and subject to recombination.

摘要

人博卡病毒（HPeV）是小 RNA 病毒科的成员，是一种主要感染儿童的传染性病原体。全球已发现 16 种公认的基因型。本研究共采集了来自泰国不同地区的 2957 份鼻咽（NP）拭子和 759 份粪便样本。在 0.4%的 NP 拭子和 6.1%的粪便样本中检测到 HPeV 的 NP。大多数 HPeV 感染发生在 2 岁以下的婴儿中，而在 10 岁以上的儿童中也检测到了感染。已鉴定出各种基因型，包括 1A、1B、2、3、4、5、6、10 和 14。本研究显示在 16 个样本中存在重组事件，其中 HPeV1B 的频率最高。总之，HPeV 可在呼吸道和胃肠道中检测到。此外，在泰国流行的 HPeV 具有高度多样性并易发生重组。