Chansaenroj Jira, Vichaiwattana Preeyaporn, Puenpa Jiratchaya, Thatsanathorn Thaksaporn, Sudhinaraset Natthinee, Wanlapakorn Nasamon, Poovorawan Yong
Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, THA.
Cureus. 2024 Feb 26;16(2):e54997. doi: 10.7759/cureus.54997. eCollection 2024 Feb.
Human enterovirus (EV) and Parechovirus (PeV) infections are major causes of sepsis-like illness in infants < 90 days of age. Enterovirus species B (EV-B) was found to be the leading cause of aseptic meningitis in young infants. In Thailand, EV and PeV are not part of the routine screening of blood or cerebrospinal fluid (CSF) of children with suspected aseptic meningitis and sepsis-like illness. Consequently, data on EV and PeV epidemiology are limited. This study tested clinical samples from hospitalized young infants with suspected aseptic meningitis or sepsis-like illness between 2013 and 2022 for EV, PeV, and Herpes simplex virus (HSV). Of 95 specimens, 10 were positive for EV, representing 10.5%. These positive samples included eight CSF and two stool samples. No samples were positive for PeV and HSV. Of these positive cases, EV-B was detected in eight, and EV-A was detected in two cases. The species of EV-B detected include echovirus-18 (E18) (n=2), E21 (n=2), E4(n=1), E5 (n=1), E9 (n=1), and E11 (n=1). Our report demonstrates the significant role of EV-B, and less frequently EV-A, in Thai infants with aseptic meningitis and sepsis-like illness.
人类肠道病毒（EV）和帕里病毒（PeV）感染是90日龄以下婴儿败血症样疾病的主要病因。肠道病毒B型（EV-B）被发现是幼儿无菌性脑膜炎的主要病因。在泰国，EV和PeV并非疑似无菌性脑膜炎和败血症样疾病儿童血液或脑脊液（CSF）常规筛查的一部分。因此，关于EV和PeV流行病学的数据有限。本研究对2013年至2022年间住院的疑似无菌性脑膜炎或败血症样疾病的幼儿临床样本进行了EV、PeV和单纯疱疹病毒（HSV）检测。在95份标本中，10份EV呈阳性，占10.5%。这些阳性样本包括8份脑脊液样本和2份粪便样本。没有样本PeV和HSV呈阳性。在这些阳性病例中，8例检测到EV-B，2例检测到EV-A。检测到的EV-B毒株包括埃可病毒18型（E18）（n = 2）、E21（n = 2）、E4（n = 1）、E5（n = 1）、E9（n = 1）和E11（n = 1）。我们的报告证明了EV-B在泰国患无菌性脑膜炎和败血症样疾病的婴儿中起重要作用，而EV-A的作用较小。
