Guo Xinyao, Xiang Jing, Mun-Bryce Sheila, Bryce Marcus, Huang Samuel, Huo Xiaolin, Wang Yingying, Rose Douglas, Degrauw Ton, Gartner Kristen, Song Tianbao, Schmit Jennifer, Vargus-Adams Jilda
Department of Human Anatomy and Histology-Embryology, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Brain Dev. 2012 Aug;34(7):576-83. doi: 10.1016/j.braindev.2011.09.012. Epub 2011 Oct 21.
Our study is to investigate somatosensory dysfunction in children with spastic cerebral palsy (CP) using magnetoencephalography (MEG) and synthetic aperture magnetometry (SAM).
Six children with spastic CP and six age- and gender-matched typically developing children were studied using a 275-channel MEG system while their left and right index fingers were stimulated in random order. The latency and amplitude of somatosensory evoked magnetic fields were analyzed at sensor level. The patterns of high-gamma oscillations were investigated with SAM at source level.
In comparison to the children with typical development, the latency of the first response of somatosensory evoked magnetic fields (SEFs) in the children with spastic CP was significantly delayed (p<0.05). High-gamma oscillations were identified in the somatosensory cortex in both children with CP and typical developing children. Interestingly, children with spastic CP had significantly higher incidence of ipsilateral activation in the somatosensory cortex following right and left finger stimulation, compared to typically developing children (p=0.05).
The results suggest that children with spastic CP have a measurable delay of SEFs and high-gamma oscillations. The high rates of ipsilateral cortical activation imply the impairments of functional lateralization in the developing brain. This is the first MEG study to demonstrate abnormal high-gamma oscillations of somatosensory cortices representing the finger in children with spastic CP.
我们的研究旨在使用脑磁图（MEG）和合成孔径磁测量法（SAM）来调查痉挛型脑瘫（CP）患儿的体感功能障碍。
对6名痉挛型CP患儿和6名年龄及性别匹配的发育正常儿童，使用275通道MEG系统进行研究，同时以随机顺序刺激他们的左右食指。在传感器水平分析体感诱发磁场的潜伏期和振幅。在源水平用SAM研究高伽马振荡模式。
与发育正常儿童相比，痉挛型CP患儿体感诱发磁场（SEFs）首次反应的潜伏期显著延迟（p<0.05）。在CP患儿和发育正常儿童的体感皮层中均发现了高伽马振荡。有趣的是，与发育正常儿童相比，痉挛型CP患儿在右手和左手手指刺激后，体感皮层同侧激活的发生率显著更高（p=0.05）。
结果表明，痉挛型CP患儿的SEFs和高伽马振荡存在可测量的延迟。同侧皮质激活率高意味着发育中大脑功能偏侧化受损。这是第一项证明痉挛型CP患儿代表手指的体感皮层存在异常高伽马振荡的MEG研究。
