Kyoto Pharmaceutical University, Misasagi, Kyoto 607-8412, Japan.
Phytomedicine. 2011 Dec 15;19(1):88-97. doi: 10.1016/j.phymed.2011.06.036. Epub 2011 Oct 22.
Yerba maté (mate) tea, a herbal tea prepared from the leaves of Ilex paraguariensis, is widely consumed in southern Latin America, and is gaining popularity worldwide. We investigated effects of an aqueous extract of mate on metabolic syndrome features in a metabolic syndrome model Tsumura Suzuki obese diabetic (TSOD) mouse. Oral administration of mate (100 mg/kg) for 7 weeks induced significant decreases in body weight, body mass index, and food intake in TSOD. It significantly decreased the hyperglycemia by reducing fasting blood glucose level, and increasing glucose uptake in glucose tolerance test. It also showed significant improvement in insulin sensitivity by increasing glucose uptake in insulin tolerance test, increasing quantitative insulin sensitivity check index, and decreasing homeostasis model assessment of insulin resistance index. The results also showed significant effects of mate on hyperlipidemia by decreasing blood levels of triglycerides, non-esterified fatty acids, and total cholesterol. Moreover, mate significantly improved adiponectin (AD) level, and exhibited significant reduction in white adipose tissue weight, and adiposity index in TSOD. It also showed significant ameliorative effects on TSOD histopathology, by reducing adipocytes proliferation, and improving hepatic steatosis. Furthermore, mate administration induced a dose-dependent delay in gastric emptying. The current data suggest that mate ameliorates metabolic syndrome by mechanisms involving increase of peripheral insulin sensitivity and cellular glucose uptake, and by modulating the level of circulating lipid metabolites and AD. These results indicate that mate can induce protective and ameliorative effects on insulin resistance, diabesity, and dyslipidemia in metabolic syndrome.
马黛茶（mate）茶，一种由巴拉圭冬青的叶子制成的草本茶，在拉丁美洲南部广泛饮用，并且在全球范围内越来越受欢迎。我们研究了马黛茶的水提取物对代谢综合征模型 Tsumura Suzuki 肥胖糖尿病（TSOD）小鼠代谢综合征特征的影响。马黛茶（100mg/kg）口服给药 7 周可显著降低 TSOD 小鼠的体重、体重指数和摄食量。它通过降低空腹血糖水平和增加葡萄糖耐量试验中的葡萄糖摄取来显著降低高血糖。它还通过增加胰岛素耐量试验中的葡萄糖摄取、增加定量胰岛素敏感性检查指数和降低胰岛素抵抗指数来显著改善胰岛素敏感性。结果还表明，马黛茶对高脂血症有显著影响，可降低甘油三酯、非酯化脂肪酸和总胆固醇的血液水平。此外，马黛茶还显著提高了脂联素（AD）水平，并降低了 TSOD 的白色脂肪组织重量和肥胖指数。它还通过减少脂肪细胞增殖和改善肝脂肪变性，对 TSOD 组织病理学表现出显著的改善作用。此外，马黛茶给药可剂量依赖性地延迟胃排空。这些数据表明，马黛茶通过增加外周胰岛素敏感性和细胞葡萄糖摄取，以及调节循环脂质代谢物和 AD 的水平，改善代谢综合征。这些结果表明，马黛茶可诱导对胰岛素抵抗、糖尿病肥胖和代谢综合征中血脂异常的保护和改善作用。
