Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK Academic Rheumatology, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK Musculoskeletal Research Centre, Faculty of Health Sciences, La Trobe University, Bundoora, Victoria 3086, Australia Institute for Aging Research, Hebrew Senior Life/Harvard Medical School, Boston, MA, USA.
Pain. 2011 Dec;152(12):2870-2880. doi: 10.1016/j.pain.2011.09.019. Epub 2011 Oct 21.
A systematic review and meta-analysis of population-based epidemiological studies was undertaken to determine the prevalence of foot and ankle pain in middle and old age. Searches were conducted in the following electronic databases from inception to October 2010: PubMed, EMBASE, AMED, CINAHL, Cochrane, PEDro, and SportDiscus. Full-text English language articles were included if they used population sample frames, cross-sectional design or analysis, and reported prevalence estimates for foot and/or ankle pain in adults aged 45 years and over. Thirty-four articles from 31 studies involving 75,505 participants provided 529 prevalence estimates based on different case definitions and population strata. Random-effects meta-analyses of studies with comparable case definitions provided pooled prevalence estimates, for frequent foot pain of 24% (95% confidence interval 22-25%; n=3; I(2)=46%) and for frequent ankle pain of 15% (95% confidence interval 13-16%; n=2; I(2)=0). Small sample sizes and low response rates in some studies, together with heterogeneous case definitions, limit confident conclusions on the distribution, subtypes, and impact of foot/ankle pain. Narrative synthesis of evidence from existing studies suggested preponderance in females, an age-related increase in prevalence in women but not men, that the toes/forefoot were the most common anatomical sites of pain, and that moderate disability in an aspect of daily life was reported by two-thirds of cases. This review provides estimates of the community burden of foot and ankle pain in middle and old age. By outlining the scale of this clinical problem, these findings can be used to inform health care planning and provision.
一项基于人群的流行病学研究的系统评价和荟萃分析旨在确定中老年人足部和踝关节疼痛的患病率。从创建到 2010 年 10 月，在以下电子数据库中进行了检索：PubMed、EMBASE、AMED、CINAHL、Cochrane、PEDro 和 SportDiscus。如果全文为英文且使用了人群样本框架、横断面设计或分析，并报告了 45 岁及以上成年人足部和/或踝关节疼痛的患病率估计值，则纳入全文。来自 31 项研究的 34 篇文章涉及 75505 名参与者，提供了基于不同病例定义和人群分层的 529 个患病率估计值。对具有可比病例定义的研究进行随机效应荟萃分析，提供了常见足部疼痛的汇总患病率估计值为 24%（95%置信区间 22-25%；n=3；I(2)=46%）和常见踝关节疼痛的汇总患病率估计值为 15%（95%置信区间 13-16%；n=2；I(2)=0）。一些研究中样本量小且应答率低，加上病例定义存在异质性，限制了对足部/踝关节疼痛的分布、亚型和影响的明确结论。对现有研究证据的叙述性综合表明，女性患病率较高，女性患病率随年龄增长而增加，但男性则不然，脚趾/前足是疼痛最常见的解剖部位，三分之二的病例报告日常生活中有中度残疾。本综述提供了中老年人足部和踝关节疼痛的社区负担估计值。通过概述这一临床问题的规模，这些发现可用于为医疗保健规划和提供提供信息。
