College of Animal Science and Technology, Yangzhou University, China.
Comp Immunol Microbiol Infect Dis. 2012 Jan;35(1):23-30. doi: 10.1016/j.cimid.2011.09.006. Epub 2011 Oct 22.
Porcine post-weaning diarrhea and edema disease are principally caused by Escherichia coli strains that produce F18 adhesin. FUT1 genotyping and receptor binding studies divided piglets into E. coli F18-resistant and -sensitive groups, and the roles of SLA-1 and SLA-3 were investigated. SLA-1 and SLA-3 expression was detected in 11 pig tissues, with higher levels of SLA-1 in lung, immune tissues and gastrointestinal tract, and higher levels of SLA-3 also in lung and lymphoid tissues. Both genes were expressed higher in F18-resistant piglets, and their expression was positively correlated in different tissues; a negative correlation was observed in some tissues of F18-sensitive group, particularly in lung and lymphatic samples. Gene ontology and pathway analyses showed that SLA-1 and SLA-3 were involved in 37 biological processes, including nine pathways related to immune functions. These observations help to elucidate the relationship between SLA class I genes and E. coli F18-related porcine gastrointestinal tract diseases.
猪断奶后腹泻和水肿病主要由产生 F18 粘附素的大肠杆菌菌株引起。FUT1 基因分型和受体结合研究将仔猪分为大肠杆菌 F18 抗性和敏感性组，并研究了 SLA-1 和 SLA-3 的作用。在 11 种猪组织中检测到 SLA-1 和 SLA-3 的表达，肺、免疫组织和胃肠道中 SLA-1 的水平较高，肺和淋巴组织中 SLA-3 的水平也较高。F18 抗性仔猪中这两个基因的表达水平较高，它们在不同组织中的表达呈正相关；在 F18 敏感性组的一些组织中观察到负相关，特别是在肺和淋巴样本中。基因本体论和途径分析表明，SLA-1 和 SLA-3 参与了 37 个生物学过程，包括与免疫功能相关的 9 个途径。这些观察结果有助于阐明 SLA 类 I 基因与大肠杆菌 F18 相关的猪胃肠道疾病之间的关系。
