有证据表明，伏隔核壳、腹侧苍白球和外侧下丘脑是侧化进食回路的组成部分。
Evidence that the nucleus accumbens shell, ventral pallidum, and lateral hypothalamus are components of a lateralized feeding circuit.
机构信息
Laboratory of Integrative Neuroscience, Department of Psychology (m/c 285), University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607-7137, United States.
出版信息
Behav Brain Res. 2012 Jan 15;226(2):548-54. doi: 10.1016/j.bbr.2011.10.014. Epub 2011 Oct 15.
Abstract
Pronounced feeding can be elicited by injections of the GABA(A) agonist muscimol into the medial shell region of the nucleus accumbens (AcbSh). This region of AcbSh has been shown to project to both the lateral hypothalamus (LH) and the medial ventral pallidum (VPm). The current study examined the effects of unilateral LH or VPm lesions on the ingestive responses induced by injections of muscimol into the AcbSh on either the same or the opposite side of the brain. We found that lesions of either of these structures drastically attenuated feeding induced from the ipsilateral, as compared to the contralateral, AcbSh. The "ipsilateral/contralateral disruption design" employed here virtually rules out the possibility that the suppressive effects of the lesions were nonspecific and suggests that the VPm and LH play essential roles in mediating the ingestive effects of inactivation of the AcbSh.
摘要
通过向伏隔核（AcbSh）的内侧壳区注射 GABA(A) 激动剂 muscimol，可以诱发明显的进食反应。AcbSh 的这一区域已被证明同时投射到外侧下丘脑（LH）和内侧腹侧苍白球（VPm）。本研究检测了单侧 LH 或 VPm 损伤对注入 AcbSh 同侧和对侧脑 muscimol 诱导的摄食反应的影响。我们发现，这些结构中的任何一种损伤都极大地削弱了与对侧相比来自同侧 AcbSh 的进食诱导。这里采用的“同侧/对侧破坏设计”几乎排除了损伤的抑制作用是非特异性的可能性，并表明 VPm 和 LH 在介导 AcbSh 失活的摄食作用中发挥了重要作用。
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