Institute of Legal Medicine, University of Zurich, 8006 Zurich, Switzerland.
Forensic Sci Int. 2012 Feb 10;215(1-3):56-9. doi: 10.1016/j.forsciint.2011.08.025. Epub 2011 Oct 22.
Hair analysis is an elaborate and time-consuming multi-step process. The immunometric test VMA-T from Comedical has been evaluated as screening assay for hair analysis. From routine work, authentic samples were selected that were positive for opiates, cocaine, MDMA-type drugs, amphetamines, methadone or THC. These hair samples were investigated by LC-MS or GC-MS and the VMA-T procedure, respectively. Using the cut-off values recommended by the Society of Hair Testing, the VMA-T method discriminates with good sensitivity between negative and positive hair samples and is an expedient screening method for drugs in keratinized matrices such as hair. In order to save time and resources, the residue of the VMA-T extraction solution can be reused for confirmation analysis by LC-MS except for cocaine.
毛发分析是一个复杂且耗时的多步骤过程。Comedical 公司的免疫分析法 VMA-T 已被评估为毛发分析的筛选检测方法。从常规工作中，选择了阿片类药物、可卡因、MDMA 类药物、苯丙胺、美沙酮或四氢大麻酚呈阳性的真实样本。这些毛发样本分别通过 LC-MS 或 GC-MS 和 VMA-T 程序进行了检测。使用毛发检测学会推荐的截止值，VMA-T 方法可以很好地区分阴性和阳性毛发样本，并且是角质基质（如毛发）中药物的一种便捷的筛选方法。为了节省时间和资源，除可卡因外，VMA-T 提取溶液的残留物可重复用于 LC-MS 的确认分析。
