Department of Pharmaceutics, Boehringer Ingelheim Pharmaceuticals, 900 Ridgebury Road, Ridgefield, CT 06877, USA.
Int J Pharm. 2011 Dec 15;421(2):203-9. doi: 10.1016/j.ijpharm.2011.10.021. Epub 2011 Oct 13.
Automatic encapsulation machines have two dosing principles: dosing disc and dosator. Dosator-based machines compress the powder to plugs that are transferred into capsules. The encapsulation process in dosator-based capsule machines was modeled in this work. A model was proposed to predict the weight and length of produced plugs. According to the model, the plug weight is a function of piston dimensions, powder-bed height, bulk powder density and precompression densification inside dosator while plug length is a function of piston height, set piston displacement, spring stiffness and powder compressibility. Powder densification within the dosator can be achieved by precompression, compression or both. Precompression densification depends on the powder to piston height ratio while compression densification depends on piston displacement against powder. This article provides the theoretical basis of the encapsulation model, including applications and limitations. The model will be applied to experimental data separately.
定量盘和定量器。基于定量器的机器将粉末压缩成塞子，然后将塞子转移到胶囊中。本工作对基于定量器的胶囊填充机的封装过程进行了建模。提出了一个模型来预测生产塞子的重量和长度。根据该模型，塞子的重量是活塞尺寸、粉末床高度、散装粉末密度和定量器内预压缩致密化的函数，而塞子的长度是活塞高度、设定活塞位移、弹簧刚度和粉末可压缩性的函数。定量器内的粉末致密化可以通过预压缩、压缩或两者兼用来实现。预压缩致密化取决于粉末与活塞高度的比值，而压缩致密化取决于活塞相对于粉末的位移。本文提供了封装模型的理论基础，包括应用和局限性。该模型将分别应用于实验数据。
