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自动胶囊填充机的仪器仪表

Instrumentation of an automatic capsule-filling machine.

作者信息

Small L E, Augsburger L L

出版信息

J Pharm Sci. 1977 Apr;66(4):504-9. doi: 10.1002/jps.2600660412.

DOI:10.1002/jps.2600660412
PMID:856971
Abstract

Techniques similar to those used in instrumenting tablet presses were applied to an automatic capsule-filling machine. The dosing unit was modified to allow the bonding of strain gauges to the compression piston. The guages formed the arms of a Wheatstone bridge circuit. Thus, compression and ejection events were monitored by measuring the bridge unbalance voltage using a suitable amplifier-recording system. The instrumented piston was calibrated in a physical testing machine. Dosing unit rotation required the interposing of a mercury contact swivel between the amplifier and instrumented piston. The instrumentation system required only one minor, permanent modification to the machine, a cut in the dosator tube. Since the same dosator piston sensed both compression and ejection, only one of the two dosing units was instrumented and the other was removed from the machine. A solenoid switching system was devised which only permitted the feeding of empty gelatin shells into the filling cycle for the instrumented piston. Representative fillers were run at constant powder bed and piston heights. Oscilloscope tracings showed two stages in slug formation: (a) "precompression," representing the force sensed during dipping of the dosator into the powder before actual compression, and (b) actual piston compression. Generally, the maximum slug compression force fell to zero rapidly on retraction of the piston, but in some cases a retention force was noted, possibly due to elastric rebound of the slug against the retracted piston. A negative deflection due to binding of the piston also was observed in tracings of one material. Lubricated batches exhibited ejection forces of less than 1 kg.

摘要

将类似于压片机使用的技术应用于自动胶囊填充机。对定量给料单元进行了改造,以便将应变片粘贴到压缩活塞上。这些应变片构成了惠斯通电桥电路的臂。因此,通过使用合适的放大记录系统测量电桥不平衡电压来监测压缩和弹出过程。在物理试验机上对装有仪器的活塞进行校准。定量给料单元的旋转需要在放大器和装有仪器的活塞之间插入一个汞接触旋转接头。该仪器系统只需要对机器进行一处较小的永久性改造,即切割定量给料管。由于同一个定量给料活塞既能感知压缩又能感知弹出,所以只对两个定量给料单元中的一个进行了仪器安装,另一个从机器上拆除。设计了一个螺线管切换系统,该系统只允许将空明胶壳送入装有仪器的活塞的填充循环中。在粉末床高度和活塞高度恒定的情况下运行代表性的填充物。示波器记录显示了团块形成的两个阶段:(a)“预压缩”,表示在实际压缩之前定量给料器浸入粉末过程中感知到的力,以及(b)活塞实际压缩。一般来说,活塞缩回时最大团块压缩力会迅速降至零,但在某些情况下会注意到有保持力,这可能是由于团块对缩回活塞的弹性反弹所致。在一种材料的记录中还观察到由于活塞粘连导致的负偏转。润滑批次的弹出力小于1千克。

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