Mizushima Y, Mori M, Ogita T, Nakamura T
Int Arch Allergy Appl Immunol. 1979;58(4):426-9. doi: 10.1159/000232222.
A new purified protein, with a molecular weight of 77,000, isolated from the supernatant of Bordetella pertussis culture fluid and called islet-activating protein (IAP), had adjuvant activity for IgE antibody in addition to leukocytosis-promoting, histamine-sensitizing and islet-activating activities. None of the three subunits (F1, F2 and F3) was biologically active by itself. All of the four activities were recovered in the complexes of subunits F1.3 and F2.3. These results suggest that the activities are brought about by a common factor inherent in B. pertussis.
从百日咳博德特氏菌培养液上清液中分离出一种新的纯化蛋白，分子量为77,000，称为胰岛激活蛋白（IAP），除了具有促进白细胞增多、组胺致敏和胰岛激活活性外，对IgE抗体还有佐剂活性。三个亚基（F1、F2和F3）单独均无生物学活性。F1.3和F2.3亚基复合物中恢复了所有四种活性。这些结果表明，这些活性是由百日咳博德特氏菌固有的一种共同因子引起的。
