Suko M, Ogita T, Okudaira H, Horiuchi Y
Int Arch Allergy Appl Immunol. 1977;54(4):329-37. doi: 10.1159/000231845.
Preferential enhancement of IgE antibody response was observed in BALF/c mice by the administration of Bordetella pertussis with antigen (DNP-Salmonella). Correlation between B cell mitogenic activity and adjuvant action among B. pertussis, Salmonella, lipopolysaccharide of Escherichia coli and Ficoll was examined but was not found. Thymus-derived cells seemed necessary to develop adjuvant action of B. pertussis since antibody response in athymic nude mice was not influenced by B. pertussis. Helper function of adoptively transfered spleen cells was enhanced by immunization of the donor mice with carrier antigen in the presence of B. pertussis. The magnitude of enhancement was greatest in IgE class. The results indicated that preferential enhancement of IgE antibody formation by B. pertussis is mediated by the augmentation of carrier-specific helper function.
通过给BALF/c小鼠接种百日咳博德特氏菌与抗原（二硝基苯基 - 沙门氏菌），观察到IgE抗体反应的优先增强。研究了百日咳博德特氏菌、沙门氏菌、大肠杆菌脂多糖和聚蔗糖之间B细胞促有丝分裂活性与佐剂作用的相关性，但未发现相关性。胸腺来源的细胞似乎是百日咳博德特氏菌发挥佐剂作用所必需的，因为无胸腺裸鼠中的抗体反应不受百日咳博德特氏菌的影响。在百日咳博德特氏菌存在的情况下，用载体抗原免疫供体小鼠可增强过继转移脾细胞的辅助功能。增强幅度在IgE类中最大。结果表明，百日咳博德特氏菌对IgE抗体形成的优先增强是由载体特异性辅助功能的增强介导的。
