Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Florianópolis-SC, Brazil.
Food Chem Toxicol. 2012 Feb;50(2):328-34. doi: 10.1016/j.fct.2011.08.028. Epub 2011 Oct 14.
Acute toxicity of yerba mate dried extract (YMDE) was investigated in Wistar rats (6/sex/group) from single dose of 2g/kg body weight by intragastric administration and 14days monitoring. Subchronic toxicity was investigated in Wistar rats, by intragastric administration (10/sex/group), and in New Zealand rabbits by oral administration (3/sex/group) of 2g/kg body weight for 12weeks. Toxicological parameters included clinical signs, body weight, water, and food consumption, hematological and serum parameters, and histopathological assessment. Acute YMDE administration showed no effects on survival, clinical observations, macroscopic examination of organs, body weight or food, and water consumption. Sub-chronic administration of YMDE did not change behavior, body weight, and histopatological assessment of stomach, kidney, liver, and small gut. Moreover, most of biochemical and hematological parameters remained unchanged. In summary, the results of our preclinical toxicological investigation are indicative that the YMDE is well tolerated for both single and chronic administration.
研究了马黛茶干提取物（YMDE）对 Wistar 大鼠（每组 6 只）的急性毒性，通过灌胃给予大鼠 2g/kg 体重的单剂量，并进行 14 天监测。通过灌胃（每组 10 只）和口服（每组 3 只）给予 Wistar 大鼠和新西兰兔 2g/kg 体重，进行为期 12 周的亚慢性毒性研究。毒理学参数包括临床症状、体重、水和食物消耗、血液学和血清参数以及组织病理学评估。急性 YMDE 给药对生存、临床观察、器官大体检查、体重或食物和水消耗没有影响。YMDE 的亚慢性给药并未改变胃、肾、肝和小肠的行为、体重和组织病理学评估。此外，大多数生化和血液学参数保持不变。总之，我们的临床前毒理学研究结果表明，YMDE 单次和慢性给药均具有良好的耐受性。
