Graduate Program in Pharmacy, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Department of Clinical Analyses, Health Sciences Center, Federal University of Santa Catarina, Trindade Campus, Florianópolis, SC, 88040-970, Brazil.
Plant Foods Hum Nutr. 2019 Dec;74(4):495-500. doi: 10.1007/s11130-019-00764-4.
The aim of the present study was to evaluate the clinical effects and antioxidant potential of spray-dried yerba mate extract (SDME) capsules in healthy individuals. Fourteen healthy volunteers consumed three capsules of SDME three times daily. Measurements were carried out at the baseline and after 7, 30, and 60 days of SDME capsules intake. Electrocardiogram, hematological, urinary, and biochemical parameters analyzed remained within the normal values during all the study. SDME capsules ingestion increased significantly serum antioxidant capacity (after 7 and 30 days) and reduced glutathione values (after 7 and 60 days), and the superoxide dismutase (after 7, 30, and 60 days), catalase (after 7 and 30 days), and paraoxonase-1 activities (after 7 days); and decreased lipid hydroperoxides (after 30 and 60 days) and thiobarbituric acid reactive substances levels (after 7 and 30 days). No change was observed for glutathione peroxidase activity after SDME capsules intake. The present study showed that SDME capsules ingestion by healthy individuals did not promote clinical changes and promoted an increase of antioxidant biomarkers with a concomitant decrease of lipid peroxidation biomarkers in a short and prolonged manner.
本研究旨在评估喷雾干燥马黛茶提取物（SDME）胶囊在健康个体中的临床效果和抗氧化潜力。14 名健康志愿者每天服用三次，每次三粒 SDME 胶囊。在 SDME 胶囊摄入的第 7、30 和 60 天分别进行了基线和测量。在整个研究期间，心电图、血液学、尿液和生化参数分析均保持在正常值范围内。SDME 胶囊摄入可显著增加血清抗氧化能力（第 7 和 30 天）和还原型谷胱甘肽值（第 7 和 60 天），以及超氧化物歧化酶（第 7、30 和 60 天）、过氧化氢酶（第 7 和 30 天）和对氧磷酶-1 活性（第 7 天）；并降低脂质过氧化物（第 30 和 60 天）和硫代巴比妥酸反应物水平（第 7 和 30 天）。SDME 胶囊摄入后，谷胱甘肽过氧化物酶活性没有变化。本研究表明，SDME 胶囊摄入对健康个体没有促进临床变化，而是在短时间和长时间内促进抗氧化生物标志物的增加，并伴随脂质过氧化生物标志物的减少。
