Spanier Gerrit, Weidt Daniela, Hellwig Dirk, Meier Johannes K H, Reichert Torsten E, Grosse Jirka
Department of Cranio-Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Department of Nuclear Medicine, University Hospital Regensburg, Regensburg, Germany.
Oncotarget. 2021 Jan 5;12(1):37-48. doi: 10.18632/oncotarget.27857.
Retrospective study to investigate the impact of image derived biomarkers from [F]FDG PET/CT prior to surgical resection in patients with initial diagnosis of oral squamous cell carcinoma (OSCC), namely SUV, SUV, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of the primary tumor to predict overall survival (OS).
127 subsequent patients with biopsy-proven OSCC were included who underwent [F]FDG PET/CT before surgery. SUV, SUV, MTV and TLG of the primary tumor were measured. OS was estimated according to Kaplan-Meier and compared between median-splitted groups by the log-rank test. Prognostic parameters were analyzed by uni-/multivariate Cox-regression.
During follow-up 52 (41%) of the patients died. Median OS was longer for patients with lower MTV or lower TLG. SUV and SUV failed to be significant predictors for OS. Univariate Cox-regression identified MTV, TLG, lymph node status and UICC stage as prognostic factors. By multivariate Cox-regression MTV and TLG turned out to be independent prognostic factors for OS.
The pre-therapeutic [F]FDG PET/CT parameters MTV and TLG in the primary tumor are prognostic for OS of patients with an initial diagnosis of OSCC. TLG is the strongest independent prognostic factor for OS and outperforms established prognostic parameters in OSCC.
进行回顾性研究，以探讨在初诊为口腔鳞状细胞癌（OSCC）的患者手术切除前，[F]FDG PET/CT图像衍生生物标志物，即原发肿瘤的SUV、SUV、代谢肿瘤体积（MTV）和总病变糖酵解（TLG）对总生存期（OS）的预测作用。
纳入127例经活检证实为OSCC且术前接受[F]FDG PET/CT检查的患者。测量原发肿瘤的SUV、SUV、MTV和TLG。根据Kaplan-Meier法估计总生存期，并通过对数秩检验比较中位数分割组之间的差异。通过单因素/多因素Cox回归分析预后参数。
随访期间52例（41%）患者死亡。MTV或TLG较低的患者中位总生存期较长。SUV和SUV未能成为总生存期的显著预测指标。单因素Cox回归分析确定MTV、TLG、淋巴结状态和国际抗癌联盟（UICC）分期为预后因素。多因素Cox回归分析显示MTV和TLG是总生存期的独立预后因素。
原发肿瘤的治疗前[F]FDG PET/CT参数MTV和TLG对初诊为OSCC患者的总生存期具有预后价值。TLG是总生存期最强的独立预后因素，优于OSCC中已确立的预后参数。
