Fossey M D, Lydiard R B
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston.
Psychiatr Med. 1990;8(3):175-86.
There is a growing recognition that a link exists between anxiety and the gastrointestinal tract. This is evident in studies examining the effects of stress on gastrointestinal function and also in studies assessing psychopathology in patients with functional gastrointestinal disorders which demonstrate a high prevalence of anxiety disorders and depression in these individuals. The recent conceptualization of anxiety as resulting from dysfunction in separable subsystems of the brain as well as experimental evidence linking the brain with the GI tract may allow for testing hypotheses that the high prevalence of anxiety in patients with functional GI disorders may be due to common or interacting pathophysiology. The similarity between the ENS and the CNS may also be a plausible explanation for this association. The high prevalence of anxiety disorders in functional GI patients suggests that medications useful in the treatment of anxiety disorders (anxiolytics and antidepressants) may be useful in the treatment of functional GI disorders especially refractory cases, but further treatment studies are needed.
人们越来越认识到焦虑与胃肠道之间存在联系。这在研究压力对胃肠功能的影响以及评估功能性胃肠疾病患者精神病理学的研究中很明显，这些研究表明这些个体中焦虑症和抑郁症的患病率很高。最近将焦虑概念化为大脑可分离子系统功能障碍的结果，以及将大脑与胃肠道联系起来的实验证据，可能有助于检验这样的假设：功能性胃肠疾病患者中焦虑症的高患病率可能是由于共同或相互作用的病理生理学。肠神经系统（ENS）和中枢神经系统（CNS）之间的相似性也可能是这种关联的一个合理的解释。功能性胃肠疾病患者中焦虑症的高患病率表明，对治疗焦虑症有用的药物（抗焦虑药和抗抑郁药）可能对治疗功能性胃肠疾病特别是难治性病例有用，但还需要进一步的治疗研究。
