Sistema de Educación Media Superior, Preparatoria 17, University of Guadalajara, Guadalajara, Mexico.
Lupus. 2012 Apr;21(4):365-72. doi: 10.1177/0961203311425517. Epub 2011 Oct 21.
Cervical human papillomavirus (HPV+) infection is associated with an increased risk of cervical dysplasia. Although the frequency of HPV+ in systemic lupus erythematosus (SLE) has been investigated in some races its prevalence in Hispanic women is still unknown. This cross-sectional study evaluated the prevalence of cervical HPV+ in Mexican women with SLE (n = 34) or rheumatoid arthritis (RA) (n = 43) and in healthy controls (n = 146). These women were interviewed about risk factors for sexually transmitted infections and cervical cytology analysis was performed. HPV+ viral types were identified using PCR: HPV+ was observed in 14.7% of SLE, 27.9% of RA and 30.8% of controls. High-risk HPV types were observed in 11.7% of women with SLE, 27.9% of women with RA, and in 26% of the controls. High-risk viral types 58, 35 and 18 were the most frequently identified in SLE. Two women with SLE had a high-grade squamous intraepithelial lesion and one had cervical cancer. An association was observed between methotrexate utilization, longer duration of therapy with prednisone, and HPV+ in RA or SLE. Thus, there is a high prevalence of cervical HPV infection in Mexican women with SLE or RA, and physicians must be vigilant in preventing the development of cervical dysplasia.
人乳头瘤病毒（HPV）感染与宫颈发育不良的风险增加有关。虽然红斑狼疮（SLE）患者中 HPV 的感染频率在某些种族中已经得到了研究，但西班牙裔妇女中 HPV 的流行情况仍不清楚。本横断面研究评估了 34 例 SLE 患者、43 例类风湿关节炎（RA）患者和 146 例健康对照者中 HPV 感染的流行情况。这些女性接受了关于性传播感染危险因素的访谈，并进行了宫颈细胞学分析。采用 PCR 鉴定 HPV 阳性病毒类型：SLE 患者中 HPV 阳性率为 14.7%，RA 患者为 27.9%，对照组为 30.8%。高危型 HPV 在 SLE 患者中占 11.7%，RA 患者中占 27.9%，对照组中占 26%。SLE 患者中最常发现的高危病毒类型为 58、35 和 18。两名 SLE 患者出现高级别鳞状上皮内病变，一名患者患有宫颈癌。在 RA 或 SLE 患者中，发现 HPV 阳性与甲氨蝶呤的使用、更长时间使用泼尼松以及 HPV 阳性有关。因此，墨西哥 SLE 或 RA 女性中存在较高的 HPV 感染流行率，医生必须警惕预防宫颈发育不良的发生。
