Skeletal anabolism, PTH, and the bone-vascular axis.
作者信息
Towler Dwight A
机构信息
Department of Medicine/Endocrine Division, Washington University in St. Louis, St. Louis, MO, USA.
出版信息
J Bone Miner Res. 2011 Nov;26(11):2579-82. doi: 10.1002/jbmr.523.
Abstract
摘要
相似文献
1
Skeletal anabolism, PTH, and the bone-vascular axis.骨骼合成代谢、甲状旁腺激素与骨-血管轴
J Bone Miner Res. 2011 Nov;26(11):2579-82. doi: 10.1002/jbmr.523.
2
Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites.间歇性 PTH(1-84)具有成骨活性但无成血管活性，可使骨髓血管向成骨部位迁移。
J Bone Miner Res. 2011 Nov;26(11):2583-96. doi: 10.1002/jbmr.459.
3
Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone.内源性和外源性甲状旁腺激素骨骼合成代谢作用机制的研究。
Arch Biochem Biophys. 2008 May 15;473(2):218-24. doi: 10.1016/j.abb.2008.03.003. Epub 2008 Mar 10.
4
Antiapoptotic molecule Bcl-2 is essential for the anabolic activity of parathyroid hormone in bone.凋亡抑制分子 Bcl-2 对于甲状旁腺激素在骨中的合成代谢活性是必需的。
Ann N Y Acad Sci. 2010 Mar;1192:330-7. doi: 10.1111/j.1749-6632.2009.05209.x.
5
Infrequent delivery of a long-acting PTH-Fc fusion protein has potent anabolic effects on cortical and cancellous bone.长效甲状旁腺激素-Fc融合蛋白的间歇性给药对皮质骨和松质骨具有强大的合成代谢作用。
J Bone Miner Res. 2007 Oct;22(10):1534-47. doi: 10.1359/jbmr.070616.
6
Postnatal deletion of β-catenin in osterix-expressing cells is necessary for bone growth and intermittent PTH-induced bone gain.成骨细胞特异性敲除β-catenin 对于骨生长和间歇性 PTH 诱导的骨量增加是必需的。
J Bone Miner Metab. 2018 Sep;36(5):560-572. doi: 10.1007/s00774-017-0873-0. Epub 2017 Nov 9.
7
Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor.甲状旁腺激素的合成作用受β2-肾上腺素能受体调节。
Proc Natl Acad Sci U S A. 2012 May 8;109(19):7433-8. doi: 10.1073/pnas.1109036109. Epub 2012 Apr 25.
8
Unique bone marrow blood vessels couple angiogenesis and osteogenesis in bone homeostasis and diseases.独特的骨髓血管在骨骼的动态平衡和疾病中结合了血管生成和成骨作用。
Ann N Y Acad Sci. 2020 Aug;1474(1):5-14. doi: 10.1111/nyas.14348. Epub 2020 Apr 3.
9
Anabolic effects of PTH and the 'anabolic window'.甲状旁腺激素的合成代谢作用和“合成代谢窗口期”。
Trends Endocrinol Metab. 2015 Mar;26(3):111-3. doi: 10.1016/j.tem.2015.01.004. Epub 2015 Feb 5.
10
[Bone histology after intermittent PTH treatment - animal models -].[间歇性甲状旁腺激素治疗后的骨组织学 - 动物模型 -]
Clin Calcium. 2013 Mar;23(3):347-53.
引用本文的文献
1
Case report: extreme coronary calcifications and hypomagnesemia in a patient with a 17q12 deletion involving HNF1B.病例报告：17q12 缺失涉及 HNF1B 的患者出现严重冠状动脉钙化和低镁血症。
BMC Nephrol. 2019 Sep 9;20(1):353. doi: 10.1186/s12882-019-1533-5.
2
FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation.成纤维细胞生长因子2（FGF2）与Wnt信号通路相互作用，介导甲状旁腺激素（PTH）对骨形成的合成代谢作用。
Bone Rep. 2018 Sep 21;9:136-144. doi: 10.1016/j.bonr.2018.09.003. eCollection 2018 Dec.
3
Adynamic bone disease is a predominant bone pattern in early stages of chronic kidney disease.动力性骨病是慢性肾脏病早期的主要骨骼表现。
J Nephrol. 2017 Oct;30(5):629-634. doi: 10.1007/s40620-017-0397-7. Epub 2017 Apr 12.
4
Calcium intake is not associated with increased coronary artery calcification: the Framingham Study.钙摄入量与冠状动脉钙化的增加无关：弗雷明汉研究。
Am J Clin Nutr. 2012 Dec;96(6):1274-80. doi: 10.3945/ajcn.112.044230. Epub 2012 Nov 7.
本文引用的文献
1
Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites.间歇性 PTH(1-84)具有成骨活性但无成血管活性，可使骨髓血管向成骨部位迁移。
J Bone Miner Res. 2011 Nov;26(11):2583-96. doi: 10.1002/jbmr.459.
2
Inhibition of tumor angiogenesis by antibodies, synthetic small molecules and natural products.抗体、合成小分子和天然产物对肿瘤血管生成的抑制作用。
Curr Med Chem. 2011;18(21):3136-55. doi: 10.2174/092986711796391570.
3
Bone and the hematopoietic niche: a tale of two stem cells.骨与造血龛：两种干细胞的故事。
Blood. 2011 May 19;117(20):5281-8. doi: 10.1182/blood-2011-01-315069. Epub 2011 Mar 15.
4
Reducing the risk of re-fracture in the dialysis population: is it time to consider therapy with PTH analogues?降低透析人群再次骨折的风险：是时候考虑使用甲状旁腺激素类似物进行治疗了吗？
Semin Dial. 2011 Jan-Feb;24(1):12-5. doi: 10.1111/j.1525-139X.2010.00817.x. Epub 2011 Feb 7.
5
Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.成骨细胞前体，而不是成熟的成骨细胞，会与入侵的血管一起进入正在发育和骨折的骨骼。
Dev Cell. 2010 Aug 17;19(2):329-44. doi: 10.1016/j.devcel.2010.07.010.
6
Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.甲状旁腺激素持续升高通过破骨细胞依赖和非依赖机制增加成骨细胞数量。
J Bone Miner Res. 2010 Nov;25(11):2427-37. doi: 10.1002/jbmr.145.
7
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow.CXCR2 和 CXCR4 拮抗调节小鼠骨髓中中性粒细胞的迁移。
J Clin Invest. 2010 Jul;120(7):2423-31. doi: 10.1172/JCI41649.
8
The bone-vascular axis in chronic kidney disease.慢性肾脏病中的骨-血管轴
Curr Opin Nephrol Hypertens. 2010 Jul;19(4):349-53. doi: 10.1097/MNH.0b013e32833a3d67.
9
Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis.血管平滑肌甲状旁腺激素受体的激活抑制糖尿病动脉硬化中的 Wnt/β-连环蛋白信号和主动脉纤维化。
Circ Res. 2010 Jul 23;107(2):271-82. doi: 10.1161/CIRCRESAHA.110.219899. Epub 2010 May 20.
10
Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding.Ephrin-B2 通过独立于 Eph 受体结合调控内皮细胞形态和运动。
J Cell Sci. 2010 Apr 15;123(Pt 8):1235-46. doi: 10.1242/jcs.061903. Epub 2010 Mar 16.
Zotero 插件