Bunse T, Schulze H J, Mahrle G
Universitäts-Hautklinik Köln.
Z Hautkr. 1990 Jun;65(6):538, 541-2.
Two groups of patients with chronic plaque psoriasis were topically treated either with 10% cyclosporin in a jelly base or with 5% cyclosporin in an ointment base under occlusion. We found that cyclosporin penetrates into the lower epidermis and the dermis, when it is applied under occlusion. Obviously, the target cells are neutrophil granulocytes, since they decrease in number under cyclosporin, whereas the other inflammatory cells as well as the epidermal proliferation remain unchanged. In contrast to systemic application of cyclosporin, we did not observe any clinical differences between plaques treated with cyclosporin and those treated with placebo.
一组使用含10%环孢素的凝胶基质制剂，另一组使用含5%环孢素的软膏基质制剂，并进行封包处理。我们发现，封包使用时环孢素可渗透至表皮下层和真皮层。显然，靶细胞是中性粒细胞，因为在环孢素治疗下其数量减少，而其他炎症细胞以及表皮增殖情况保持不变。与环孢素全身应用不同，我们未观察到用环孢素治疗的斑块与用安慰剂治疗的斑块之间存在任何临床差异。
