Lin Yin-Ku, Wong Wen-Rou, Chang Ya-Ching, Chang Chee-Jen, Tsay Pei-Kwei, Chang Shu-Chen, Pang Jong-Hwei Su
Department of Traditional Chinese Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC.
Dermatology. 2007;214(2):155-61. doi: 10.1159/000098576.
It has been reported in the Chinese literature that indigo naturalis exhibits potential antipsoriatic effects in systemic therapy.
To evaluate the efficacy and safety of topically applied indigo naturalis on treating plaque-type psoriasis and to analyze the histological change in skin tissues.
Fourteen patients with chronic plaque psoriasis were enrolled. The patients were topically applied with either indigo naturalis ointment or vehicle ointment on contralateral skin lesions daily for 8 weeks. Efficacy was evaluated on the basis of the clinical scores, including induration, scaling, erythema and clearing percentage. At the end of treatment, skin punch biopsies were taken and prepared for the immunohistochemical analysis.
A significant reduction in clinical scores was achieved with topically applied indigo naturalis ointment. Analysis of biopsies showed a marked improvement of skin histology. The expressions of proliferating marker Ki-67 and inflammatory marker CD3 were decreased, but the differentiation marker such as filaggrin was increased in the epidermis after indigo naturalis ointment treatment.
The results suggest that topical application of indigo naturalis ointment may be a novel, safe and effective therapy for psoriasis that is mediated, at least in part, by modulating the proliferation and differentiation of keratinocytes in epidermis, as well as by inhibiting the infiltration of T lymphocytes and therefore the subsequent inflammatory reactions in psoriatic lesions.
中国文献报道，青黛在全身治疗中显示出潜在的抗银屑病作用。
评估外用青黛治疗斑块型银屑病的疗效和安全性，并分析皮肤组织的组织学变化。
招募14例慢性斑块型银屑病患者。患者双侧皮损分别每日外用青黛软膏或赋形剂软膏，共8周。根据硬结、鳞屑、红斑和清除率等临床评分评估疗效。治疗结束时，取皮肤打孔活检标本，准备进行免疫组化分析。
外用青黛软膏可使临床评分显著降低。活检分析显示皮肤组织学有明显改善。青黛软膏治疗后，表皮中增殖标志物Ki-67和炎症标志物CD3的表达降低，但角蛋白聚积蛋白等分化标志物增加。
结果表明，外用青黛软膏可能是一种治疗银屑病的新型、安全有效的疗法，其作用机制至少部分是通过调节表皮角质形成细胞的增殖和分化，以及抑制T淋巴细胞浸润，从而抑制银屑病皮损中的后续炎症反应。
