Dimal P, Wilders-Truschnig M, Leb G, Beham A, Eber O, Hebenstreit J, Loidolt D, Dohr G, Lanzer G
Department of Internal Medicine, School of Medicine, Karl Franzens University Graz, Austria.
Acta Med Austriaca. 1990;17 Suppl 1:43.
This study describes dendritic cells in thyroid sections of iodine deficient goiters. Cells were characterized by monoclonal markers and detected by immunohistochemistry and double labelling immunofluorescence. We observed dendritic cells located in focal aggregates in the interstitium and epitheloid cells as well as multinucleated giant cells filling thyroid follicles. All these cells showed strong positivity for the MHC class II molecules HLA-DR, -DQ, -DP and RFD1, a monoclonal marker for active antigen presenting cells.
本研究描述了碘缺乏性甲状腺肿甲状腺切片中的树突状细胞。通过单克隆标志物对细胞进行特征鉴定，并采用免疫组织化学和双标记免疫荧光法进行检测。我们观察到树突状细胞位于间质中的局灶性聚集处，上皮样细胞以及充满甲状腺滤泡的多核巨细胞中。所有这些细胞对MHC II类分子HLA-DR、-DQ、-DP以及活性抗原呈递细胞的单克隆标志物RFD1均呈强阳性反应。
