Waalen K, Førre O, Teigland J, Natvig J B
Institute of Immunology and Rheumatology, National Hospital, University of Oslo, Norway.
Clin Exp Immunol. 1987 Oct;70(1):1-9.
Rheumatoid dendritic cells (DC) from synovial membrane and synovial fluid and normal dendritic cells from peripheral blood were compared with autologous monocytes concerning accessory activities for T cell antigen responses. Purified protein derivative of tuberculin (PPD), herpes simplex virus type 1 antigen (HSV) and Chlamydia trachomatis antigen were used as antigens. The dendritic cells were shown to be efficient antigen presenting cells for the various antigens and were much more potent than monocytes. The DC were strongly positive for major histocompatibility complex (MHC) class II antigens. The T cell responses both to bacterial and viral antigens induced by DC could all be inhibited by monoclonal antibodies against HLA-DQ and HLA-DR antigens. Dendritic cells may thus play an important role as accessory cells in presenting antigens for T cells in the context fo class II MHC molecules in the rheumatoid inflammation.
将来自滑膜和滑液的类风湿树突状细胞（DC）以及来自外周血的正常树突状细胞与自体单核细胞在T细胞抗原应答的辅助活性方面进行了比较。使用结核菌素纯蛋白衍生物（PPD）、1型单纯疱疹病毒抗原（HSV）和沙眼衣原体抗原作为抗原。结果显示，树突状细胞是针对各种抗原的高效抗原呈递细胞，其效力远高于单核细胞。DC对主要组织相容性复合体（MHC）II类抗原呈强阳性。DC诱导的针对细菌和病毒抗原的T细胞应答均可被抗HLA-DQ和HLA-DR抗原的单克隆抗体抑制。因此，在类风湿性炎症中，树突状细胞作为辅助细胞在II类MHC分子环境中为T细胞呈递抗原时可能发挥重要作用。
