• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Sporolide B: Synthetic Studies.sporolide B：合成研究。
Tetrahedron. 2011 Sep 2;67(35):6697-6706. doi: 10.1016/j.tet.2011.04.094.
2
Total synthesis of sporolide B and 9-epi-sporolide B.sporolide B 和 9-epi-sporolide B 的全合成。
J Am Chem Soc. 2010 Aug 18;132(32):11350-63. doi: 10.1021/ja1048994.
3
Total synthesis of sporolide B.sporolide B的全合成
Angew Chem Int Ed Engl. 2009;48(19):3449-53. doi: 10.1002/anie.200900264.
4
Total Synthesis and Complete Stereostructure of a Marine Macrolide Glycoside, (-)-Lyngbyaloside B.一种海洋大环内酯糖苷（-）-林格比糖苷B的全合成及完整立体结构
Chemistry. 2016 May 10;22(20):6815-29. doi: 10.1002/chem.201600341. Epub 2016 Apr 26.
5
Total Synthesis of Eribulin, a Macrocyclic Ketone Analogue of Halichondrin B, via Prins Macrocyclization.
Org Lett. 2025 Jan 31;27(4):927-931. doi: 10.1021/acs.orglett.4c03893. Epub 2024 Dec 31.
6
Structural basis for precursor protein-directed ribosomal peptide macrocyclization.前体蛋白导向的核糖体肽大环化的结构基础。
Nat Chem Biol. 2016 Nov;12(11):973-979. doi: 10.1038/nchembio.2200. Epub 2016 Sep 26.
7
A sterically encumbered photoredox catalyst enables the unified synthesis of the classical lignan family of natural products.一种空间位阻光氧化还原催化剂能够实现天然产物经典木脂素家族的统一合成。
Chem Sci. 2019 Jul 5;10(33):7746-7754. doi: 10.1039/c9sc02682g. eCollection 2019 Sep 7.
8
Total synthesis of (+)-vinblastine: control of the stereochemistry at C18'.（+）-长春碱的全合成：C18 位立体化学控制。
Chem Rec. 2010 Apr;10(2):101-18. doi: 10.1002/tcr.201090001.
9
Cycloadditions in the total synthesis of sporolide B.
Angew Chem Int Ed Engl. 2009;48(28):5078-80. doi: 10.1002/anie.200901894.
10
Synthesis of IB-01211, a cyclic peptide containing 2,4-concatenated thia- and oxazoles, via Hantzsch macrocyclization.通过汉茨希大环化反应合成IB-01211，一种含有2,4-串联噻唑和恶唑的环肽。
Org Lett. 2007 Mar 1;9(5):809-11. doi: 10.1021/ol063023c. Epub 2007 Feb 1.

引用本文的文献

1
Evolution of a Unified Strategy for Complex Sesterterpenoids: Progress toward Astellatol and the Total Synthesis of (-)-Nitidasin.复杂倍半萜类化合物统一策略的演进：向阿斯泰拉醇及（-）-尼替达辛全合成的进展
Chemistry. 2015 Sep 21;21(39):13646-65. doi: 10.1002/chem.201501423. Epub 2015 Aug 20.

本文引用的文献

1
Total synthesis of sporolide B.sporolide B的全合成
Angew Chem Int Ed Engl. 2009;48(19):3449-53. doi: 10.1002/anie.200900264.
2
Unraveling the biosynthesis of the sporolide cyclohexenone building block.解析sporolide环己烯酮结构单元的生物合成过程。
J Am Chem Soc. 2008 Feb 27;130(8):2406-7. doi: 10.1021/ja710488m. Epub 2008 Jan 31.
3
Synthesis of the sporolide ring framework through a cascade sequence involving an intramolecular [4+2] cycloaddition reaction of an o-quinone.通过涉及邻醌的分子内[4+2]环加成反应的串联序列合成sporolide环骨架。
Angew Chem Int Ed Engl. 2008;47(8):1432-5. doi: 10.1002/anie.200705334.
4
Enantioselective total synthesis of (-)-Salinosporamide A (NPI-0052).(-)-盐霉素A（NPI-0052）的对映选择性全合成
Org Lett. 2007 Jun 7;9(12):2289-92. doi: 10.1021/ol0706051. Epub 2007 May 12.
5
Concise total synthesis of (+/-)-salinosporamide A, (+/-)-cinnabaramide A, and derivatives via a bis-cyclization process: implications for a biosynthetic pathway?通过双环化过程对（±）-盐霉素A、（±）-肉桂酰胺A及其衍生物进行简洁的全合成：对生物合成途径有何启示？
Org Lett. 2007 May 24;9(11):2143-6. doi: 10.1021/ol070616u. Epub 2007 May 4.
6
Nucleophilic addition to a p-benzyne derived from an enediyne: a new mechanism for halide incorporation into biomolecules.亲核试剂对源自烯二炔的对苯炔的加成反应：卤化物掺入生物分子的新机制。
J Am Chem Soc. 2007 Apr 18;129(15):4795-9. doi: 10.1021/ja070023e. Epub 2007 Mar 23.
7
Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1.重氮苯并芴抗生素（-）-金霉素C1的全合成。
J Am Chem Soc. 2006 Nov 22;128(46):14790-1. doi: 10.1021/ja066621v.
8
Discovery of novel metabolites from marine actinomycetes.从海洋放线菌中发现新型代谢产物。
Curr Opin Microbiol. 2006 Jun;9(3):245-51. doi: 10.1016/j.mib.2006.03.004. Epub 2006 May 3.
9
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.一种新型口服活性蛋白酶体抑制剂通过不同于硼替佐米的机制诱导多发性骨髓瘤细胞凋亡。
Cancer Cell. 2005 Nov;8(5):407-19. doi: 10.1016/j.ccr.2005.10.013.
10
Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica.孢子内酯A和B：来自海洋放线菌热带盐孢菌的结构前所未有的卤代大环内酯类化合物。
Org Lett. 2005 Jun 23;7(13):2731-4. doi: 10.1021/ol050901i.

sporolide B：合成研究。

Sporolide B: Synthetic Studies.

作者信息

Gladding Jeffery A, Bacci James P, Shaw Scott A, Smith Amos B

机构信息

Department of Chemistry, Monell Chemical Senses Center and Laboratory of Research on the Structure of Matter, University of Pennsylvania, Philadelphia, PA 19104, United States.

出版信息

Tetrahedron. 2011 Sep 2;67(35):6697-6706. doi: 10.1016/j.tet.2011.04.094.

DOI:10.1016/j.tet.2011.04.094
PMID:22021939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3197724/
Abstract

Studies directed towards the synthesis of the architecturally complex marine natural product sporolide B are described. Synthetic analysis suggested advanced hydroquinone and benzodiquinane fragments, which upon elaboration were successfully united via an ester linkage. Macrocyclization studies were then carried out, and although a novel macrocyclization product was obtained, subsequent studies revealed that the tertiary hydroxyls at C(6) and C(10) were sterically encumbered to participate in a successful macrocyclization to furnish sporolide B.

摘要

本文描述了针对结构复杂的海洋天然产物sporolide B的合成研究。合成分析表明了高级对苯二酚和苯并二喹烷片段，经精心构建后通过酯键成功结合在一起。然后进行了大环化研究，虽然得到了一种新型大环化产物，但后续研究表明，C(6)和C(10)位的叔羟基在空间上受到阻碍，无法成功参与大环化反应以生成sporolide B。