Lam Kin S
Department of Microbiology and Anti-infective Discovery, Nereus Pharmaceuticals, Inc., 10480 Wateridge Circle, San Diego, CA 92121, USA.
Curr Opin Microbiol. 2006 Jun;9(3):245-51. doi: 10.1016/j.mib.2006.03.004. Epub 2006 May 3.
Recent findings from culture-dependent and culture-independent methods have demonstrated that indigenous marine actinomycetes exist in the oceans and are widely distributed in different marine ecosystems. There is tremendous diversity and novelty among the marine actinomycetes present in marine environments. Progress has been made to isolate novel actinomycetes from samples collected at different marine environments and habitats. These marine actinomycetes produce different types of new secondary metabolites. Many of these metabolites possess biological activities and have the potential to be developed as therapeutic agents. Marine actinomycetes are a prolific but underexploited source for the discovery of novel secondary metabolites.
依赖培养和不依赖培养的方法最近的研究结果表明，海洋土著放线菌存在于海洋中，并广泛分布于不同的海洋生态系统。海洋环境中存在的海洋放线菌具有巨大的多样性和新颖性。从不同海洋环境和栖息地采集的样本中分离新型放线菌已取得进展。这些海洋放线菌产生不同类型的新次生代谢产物。其中许多代谢产物具有生物活性，有潜力被开发为治疗药物。海洋放线菌是发现新型次生代谢产物的丰富但未充分利用的来源。
