Suganya Subramanian, Sophia Dominic, Raj Chinthamony Arul, Rathi Muthaiyan Ahalliya, Thirumoorthi Lakshmanan, Meenakshi Periyasamy, Kumar Dugganaboyana Guru, Gopalakrishnan Velliyur Kanniyapan
Department of Biochemistry, Karpagam Arts and Science College, Coimbatore - 641 021, Tamil Nadu, India.
Pharmacognosy Res. 2011 Jul;3(3):201-7. doi: 10.4103/0974-8490.85009.
Euphorbia hirta (L.) (Euphorbiaceae) is a very popular herb amongst practitioners of traditional medicine and used in the treatment of female disorders, respiratory ailments, tumors, jaundice, digestive problems, wounds, etc. We aimed to evaluate the protective effect of E. hirta against nitrobenzene-induced nephrotoxicity in albino rats.
The nephroprotective activity of the ethanol extract of E. hirta (400 mg/kg body weight) was studied in nitrobenzene-induced albino rats (1000 mg/kg body weight). The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and the levels of reduced glutathione (GSH), total thiols and vitamin C in the kidney tissues were determined. Histopathologic investigation was performed in the kidney tissue samples.
Nitrobenzene administration significantly (P < 0.01) enhanced the lipid peroxidation and significantly (P < 0.05) depleted the levels of SOD, CAT, GPx, GST, GSH, total thiols and vitamin C. Treatment with the ethanol extract of E. hirta significantly normalized the antioxidant levels. The nephroprotective activity was also supported by histopathologic studies of kidney tissue.
The results indicate that the ethanol extract of E. hirta ameliorates renal dysfunction and could be used as an effective protector against nitrobenzene-induced nephrotoxicity, primarily through its antioxidant capacity.
大戟草（大戟科）是传统医学从业者中非常受欢迎的一种草药，用于治疗女性疾病、呼吸道疾病、肿瘤、黄疸、消化问题、伤口等。我们旨在评估大戟草对白化病大鼠硝基苯诱导的肾毒性的保护作用。
研究了大戟草乙醇提取物（400毫克/千克体重）对硝基苯诱导的白化病大鼠（1000毫克/千克体重）的肾保护活性。测定了肾组织中抗氧化酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽-S-转移酶（GST）的活性，以及还原型谷胱甘肽（GSH）、总硫醇和维生素C的水平。对肾组织样本进行了组织病理学研究。
给予硝基苯显著（P<0.01）增强了脂质过氧化作用，并显著（P<0.05）降低了SOD、CAT、GPx、GST、GSH、总硫醇和维生素C的水平。用大戟草乙醇提取物治疗显著使抗氧化水平恢复正常。肾组织的组织病理学研究也支持了其肾保护活性。
结果表明，大戟草乙醇提取物可改善肾功能障碍，主要通过其抗氧化能力，可作为对抗硝基苯诱导的肾毒性的有效保护剂。
