Yvette Fofie N'Guessan Bra, Sanogo Rokia, Coulibaly Kiyinlma, Kone-Bamba Diénéba
Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët Boigny Cocody-Abidjan, 22 BP 747 Abidjan 22, Côte d'Ivoire.
Department of Traditional Medicine, Faculty of Pharmaceutical Sciences University of Bamako Mali ; Faculty of Pharmaceutical Sciences of Bamako, Bamako, Mali.
Pharmacognosy Res. 2015 Jan-Mar;7(1):7-13. doi: 10.4103/0974-8490.147131.
Phytochemical study and research on acute toxicity were performed on the aerial parts (leaves and stems) of Euphorbia hirta Linn. The phytochemical screening and chromatography revealed the presence of saponin, sterol, terpene, alkaloids, polyphenols, tannins and flavonoids and especially mucilage. The evaluation of total polyphenols and total flavonoids gave 120.97 ± 7.07 gallic acid equivalents (GAE) mg/g (mg of GAE/g of extract) of dry extract and 41.4 ± 0.5 mg quercetin equivalent per gram (QE/g) (mg of QE/g of plant extract) of dry extract respectively. The physicochemical study revealed moisture content of 7.73% ± 0.00%, total ash 7.48% ± 0.03%. Sulfuric ash 9.05% ± 0.01%, hydrochloric acid insoluble ash of 0.8% ± 0.02%. The search for minerals salt revealed the presence of Cr, Zn, K, Ca and Mg having an important role in glucose metabolism. The acute toxicity study showed that the toxic dose may be above 3000 mg/kg. The results of these studies indicate that extracts from the leaves and stem of E. hirta Linn. contains trace elements and minerals salt and bioactive secondary metabolites which explain their therapeutic uses for treating diabetes mellitus.
对大戟属植物飞扬草的地上部分（叶和茎）进行了植物化学研究和急性毒性研究。植物化学筛选和色谱分析表明，其中存在皂苷、甾醇、萜类、生物碱、多酚、单宁和黄酮类化合物，尤其是黏液质。总多酚和总黄酮的评估结果分别为每克干提取物含120.97±7.07没食子酸当量（GAE）毫克（GAE毫克/克提取物）和每克干提取物含41.4±0.5毫克槲皮素当量（QE/克）（QE毫克/克植物提取物）。理化研究表明，水分含量为7.73%±0.00%，总灰分为7.48%±0.03%，硫酸灰分为9.05%±0.01%，盐酸不溶性灰分为0.8%±0.02%。对矿物盐的检测发现其中存在铬、锌、钾、钙和镁，它们在葡萄糖代谢中起重要作用。急性毒性研究表明，毒性剂量可能高于3000毫克/千克。这些研究结果表明，飞扬草叶和茎的提取物含有微量元素、矿物盐和生物活性次生代谢产物，这解释了它们在治疗糖尿病方面的药用价值。
