Ragheb Ahmed, Attia Ahmed, Eldin Walid Shehab, Elbarbry Fawzy, Gazarin Sana, Shoker Ahmed
Department of Medicine, Division of Nephrology, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada.
Saudi J Kidney Dis Transpl. 2009 Sep;20(5):741-52.
Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including anti-oxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulonephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demonstrated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans.
百里醌（TQ），即2-异丙基-5-甲基-1,4-苯醌，是黑种草籽中最具活性的成分之一。TQ具有多种有益特性，包括抗氧化和抗炎活性。研究已对氧化应激和炎症在诸如肾小球肾炎和药物性肾毒性等肾脏疾病发展中的作用提供了原始观察结果。TQ的肾脏保护作用已在动物模型中得到证实。此外，TQ已成功用于治疗人类的过敏性疾病。本综述的目的是强调活性氧在肾脏病理生理学中的重要性，以及TQ在预防和/或保护人类免受肾损伤方面发挥作用的有趣可能性。
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