恶性疟原虫疫苗试验中夜猴的肾脏病理学

Renal pathology in owl monkeys in Plasmodium falciparum vaccine trials.

作者信息

Iseki M, Broderson J R, Pirl K G, Igarashi I, Collins W E, Aikawa M

机构信息

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio.

出版信息

Am J Trop Med Hyg. 1990 Aug;43(2):130-8. doi: 10.4269/ajtmh.1990.43.130.

DOI:10.4269/ajtmh.1990.43.130

PMID:2202223

Abstract

Renal specimens of 16 owl monkeys (Aotus vociferans) were studied by light microscopy and immunohistochemistry during a vaccine trial with recombinant proteins of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum. Deposition of IgG, C3, and P. falciparum antigens in the mesangium was demonstrated by the peroxidase anti-peroxidase (PAP) method. A relationship between the severity of parasitemia at the time of death and the presence of nephropathy was not apparent.

摘要

在一项使用恶性疟原虫环状感染红细胞表面抗原（RESA）重组蛋白的疫苗试验期间，对16只夜猴（Aotus vociferans）的肾脏标本进行了光学显微镜和免疫组织化学研究。通过过氧化物酶抗过氧化物酶（PAP）方法证实了系膜中IgG、C3和恶性疟原虫抗原的沉积。死亡时的寄生虫血症严重程度与肾病的存在之间的关系并不明显。