Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
Cancer Res Treat. 2011 Sep;43(3):199-203. doi: 10.4143/crt.2011.43.3.199. Epub 2011 Sep 30.
Eosinophils are derived from hematopoietic stem cells. Peripheral blood eosinophilia is defined as an absolute eosinophil count of ≥0.5×10(9)/L. Eosinophilia is classified into primary or clonal eosinophilia, secondary eosinophilia, and idiopathic categories including idiopathic hypereosinophilic syndrome. Both hematopoietic and solid neoplasms may be associated with peripheral blood eosinophilia, but multiple myeloma is rarely associated with eosinophilia. We now report the case of a 31-year-old man with multiple myeloma associated with marked eosinophilia who developed multiple organ dysfunction with infiltration of eosinophils. He recovered after treatment with chemotherapy followed by autologous stem cell transplantation.
嗜酸性粒细胞来源于造血干细胞。外周血嗜酸性粒细胞增多定义为绝对嗜酸性粒细胞计数≥0.5×10(9)/L。嗜酸性粒细胞增多分为原发性或克隆性嗜酸性粒细胞增多、继发性嗜酸性粒细胞增多和特发性，包括特发性嗜酸性粒细胞增多综合征。造血和实体肿瘤均可伴有外周血嗜酸性粒细胞增多，但多发性骨髓瘤很少伴有嗜酸性粒细胞增多。我们现报告 1 例伴明显嗜酸性粒细胞增多的多发性骨髓瘤患者，其发生多器官功能障碍，伴有嗜酸性粒细胞浸润。他在接受化疗和自体造血干细胞移植治疗后康复。
