定量蛋白质组学揭示了恶性疟原虫入侵红细胞的新见解。
Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.
机构信息
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
出版信息
Mol Cell Proteomics. 2012 Feb;11(2):M111.010645. doi: 10.1074/mcp.M111.010645. Epub 2011 Oct 24.
Abstract
Differential expression of ligands in the human malaria parasite Plasmodium falciparum enables it to recognize different receptors on the erythrocyte surface, thereby providing alternative invasion pathways. Switching of invasion from using sialated to nonsialated erythrocyte receptors has been linked to the transcriptional activation of a single parasite ligand. We have used quantitative proteomics to show that in addition to this single known change, there are a significant number of changes in the expression of merozoite proteins that are regulated independent of transcription during invasion pathway switching. These results demonstrate a so far unrecognized mechanism by which the malaria parasite is able to adapt to variations in the host cell environment by post-transcriptional regulation.
摘要
人疟原虫疟原虫中配体的差异表达使其能够识别红细胞表面的不同受体，从而提供替代的入侵途径。从使用唾液酸化的红细胞受体到非唾液酸化的红细胞受体的入侵转换已被证明与单一寄生虫配体的转录激活有关。我们已经使用定量蛋白质组学表明，除了这种单一的已知变化外，在入侵途径转换过程中，有大量的裂殖子蛋白的表达变化是独立于转录的调节。这些结果表明，疟原虫通过转录后调控来适应宿主细胞环境变化的一种迄今尚未被认识的机制。
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本文引用的文献
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