• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.定量蛋白质组学揭示了恶性疟原虫入侵红细胞的新见解。
Mol Cell Proteomics. 2012 Feb;11(2):M111.010645. doi: 10.1074/mcp.M111.010645. Epub 2011 Oct 24.
2
Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairs parasite invasion of erythrocytes.恶性疟原虫裂殖子表面蛋白7基因的缺失会损害寄生虫对红细胞的入侵。
Eukaryot Cell. 2008 Dec;7(12):2123-32. doi: 10.1128/EC.00274-08. Epub 2008 Sep 26.
3
Proteome analysis reveals a large merozoite surface protein-1 associated complex on the Plasmodium falciparum merozoite surface.蛋白质组分析揭示恶性疟原虫裂殖子表面的一个大型裂殖子表面蛋白 1 相关复合物。
J Proteome Res. 2011 Feb 4;10(2):680-91. doi: 10.1021/pr100875y. Epub 2010 Dec 22.
4
Evidence that the Malaria Parasite Plasmodium falciparum Putative Rhoptry Protein 2 Localizes to the Golgi Apparatus throughout the Erythrocytic Cycle.疟原虫恶性疟原虫推定的棒状体蛋白2在整个红细胞周期定位于高尔基体的证据。
PLoS One. 2015 Sep 16;10(9):e0138626. doi: 10.1371/journal.pone.0138626. eCollection 2015.
5
A novel Plasmodium falciparum erythrocyte binding protein associated with the merozoite surface, PfDBLMSP.一种与裂殖子表面相关的新型恶性疟原虫红细胞结合蛋白 PfDBLMSP。
Int J Parasitol. 2009 Jun;39(7):763-73. doi: 10.1016/j.ijpara.2008.12.004.
6
Profiling invasive Plasmodium falciparum merozoites using an integrated omics approach.采用整合组学方法对侵袭性疟原虫裂殖子进行分析。
Sci Rep. 2017 Dec 7;7(1):17146. doi: 10.1038/s41598-017-17505-9.
7
Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania.在来自坦桑尼亚的恶性疟原虫分离株中，变异裂殖子蛋白表达与红细胞入侵表型相关。
Mol Biochem Parasitol. 2007 May;153(1):66-71. doi: 10.1016/j.molbiopara.2007.01.007. Epub 2007 Jan 16.
8
Sequential processing of merozoite surface proteins during and after erythrocyte invasion by Plasmodium falciparum.恶性疟原虫入侵红细胞过程中和入侵后裂殖子表面蛋白的连续加工。
Infect Immun. 2014 Mar;82(3):924-36. doi: 10.1128/IAI.00866-13. Epub 2013 Nov 11.
9
Application of optical tweezer technology reveals that PfEBA and PfRH ligands, not PfMSP1, play a central role in Plasmodium falciparum merozoite-erythrocyte attachment.光学镊子技术的应用表明，PfEBA 和 PfRH 配体而非 PfMSP1 在恶性疟原虫裂殖子-红细胞黏附中起核心作用。
PLoS Pathog. 2024 Sep 23;20(9):e1012041. doi: 10.1371/journal.ppat.1012041. eCollection 2024 Sep.
10
Identification and characterization of a novel Plasmodium falciparum merozoite apical protein involved in erythrocyte binding and invasion.一种参与红细胞结合与入侵的新型恶性疟原虫裂殖子顶端蛋白的鉴定与特性分析
PLoS One. 2008 Mar 5;3(3):e1732. doi: 10.1371/journal.pone.0001732.

引用本文的文献

1
Integrative Transcriptome and Proteome Analysis Identifies Major Molecular Regulation Pathways Involved in Ramie ( (L.) Gaudich) under Nitrogen and Water Co-Limitation.整合转录组和蛋白质组分析确定了苎麻（Boehmeria nivea (L.) Gaudich）在氮和水共同限制下涉及的主要分子调控途径。
Plants (Basel). 2020 Sep 25;9(10):1267. doi: 10.3390/plants9101267.
2
Transcriptome and proteome analyses reveal the regulatory networks and metabolite biosynthesis pathways during the development of .转录组和蛋白质组分析揭示了……发育过程中的调控网络和代谢物生物合成途径。 （原文中“during the development of.”后面缺少具体内容）
Comput Struct Biotechnol J. 2020 Jul 25;18:2081-2094. doi: 10.1016/j.csbj.2020.07.014. eCollection 2020.
3
Differential protein expression analysis following olfactory learning in Apis cerana.中华蜜蜂嗅觉学习后的差异蛋白质表达分析
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015 Nov;201(11):1053-61. doi: 10.1007/s00359-015-1042-3. Epub 2015 Oct 1.
4
Integration of the proteome and transcriptome reveals multiple levels of gene regulation in the rice dl2 mutant.蛋白质组和转录组的整合揭示了水稻dl2突变体中基因调控的多个层次。
Front Plant Sci. 2015 Jun 17;6:351. doi: 10.3389/fpls.2015.00351. eCollection 2015.
5
P-selectin is a host receptor for Plasmodium MSP7 ligands.P-选择素是疟原虫MSP7配体的宿主受体。
Malar J. 2015 Jun 5;14:238. doi: 10.1186/s12936-015-0750-z.
6
Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers.患脑型疟疾儿童与无症状携带者体内恶性疟原虫基因转录组模式的差异。
PLoS One. 2014 Dec 5;9(12):e114401. doi: 10.1371/journal.pone.0114401. eCollection 2014.
7
Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum.恶性疟原虫入侵红细胞过程中关键钙信号的触发。
Nat Commun. 2013;4:2862. doi: 10.1038/ncomms3862.
8
Food vacuole associated enolase in plasmodium undergoes multiple post-translational modifications: evidence for atypical ubiquitination.疟原虫中与食物泡相关的烯醇酶经历多种翻译后修饰：非典型泛素化的证据。
PLoS One. 2013 Aug 23;8(8):e72687. doi: 10.1371/journal.pone.0072687. eCollection 2013.
9
Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development.疟原虫红内期发育三个阶段的蛋白质表达和磷酸化的全局分析。
J Proteome Res. 2013 Sep 6;12(9):4028-45. doi: 10.1021/pr400394g. Epub 2013 Aug 26.
10
Deletion of Synechocystis sp. PCC 6803 leader peptidase LepB1 affects photosynthetic complexes and respiration.缺失集胞藻 PCC 6803 的领导肽酶 LepB1 会影响光合作用复合物和呼吸作用。
Mol Cell Proteomics. 2013 May;12(5):1192-203. doi: 10.1074/mcp.M112.022145. Epub 2013 Jan 28.

本文引用的文献

1
Proteome analysis reveals a large merozoite surface protein-1 associated complex on the Plasmodium falciparum merozoite surface.蛋白质组分析揭示恶性疟原虫裂殖子表面的一个大型裂殖子表面蛋白 1 相关复合物。
J Proteome Res. 2011 Feb 4;10(2):680-91. doi: 10.1021/pr100875y. Epub 2010 Dec 22.
2
All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay.万物终消逝：真核生物与细菌 mRNA 衰变的差异与共性。
Nat Rev Mol Cell Biol. 2010 Jul;11(7):467-78. doi: 10.1038/nrm2917. Epub 2010 Jun 3.
3
Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development.转录后基因调控的普遍特征对疟原虫合子发育至关重要。
PLoS Pathog. 2010 Feb 12;6(2):e1000767. doi: 10.1371/journal.ppat.1000767.
4
Expansion of the eukaryotic proteome by alternative splicing.通过选择性剪接扩展真核生物蛋白质组。
Nature. 2010 Jan 28;463(7280):457-63. doi: 10.1038/nature08909.
5
Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion.疟原虫入侵红细胞的受体蛋白可变表达的表观遗传控制。
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2224-9. doi: 10.1073/pnas.0913396107. Epub 2010 Jan 13.
6
Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum.人类疟原虫恶性疟原虫生长干扰的转录谱分析。
Nat Biotechnol. 2010 Jan;28(1):91-8. doi: 10.1038/nbt.1597. Epub 2009 Dec 27.
7
Targeting proteins for degradation.靶向蛋白质降解。
Nat Chem Biol. 2009 Nov;5(11):815-22. doi: 10.1038/nchembio.250.
8
Regulation of gene expression and cellular proliferation by histone H2A.Z.组蛋白H2A.Z对基因表达和细胞增殖的调控
Biochem Cell Biol. 2009 Feb;87(1):179-88. doi: 10.1139/O08-138.
9
Connection between histone H2A variants and chromatin remodeling complexes.组蛋白H2A变体与染色质重塑复合物之间的联系。
Biochem Cell Biol. 2009 Feb;87(1):35-50. doi: 10.1139/O08-140.
10
Transcriptional and epigenetic functions of histone variant H2A.Z.组蛋白变体H2A.Z的转录和表观遗传功能
Biochem Cell Biol. 2009 Feb;87(1):19-25. doi: 10.1139/O08-117.

定量蛋白质组学揭示了恶性疟原虫入侵红细胞的新见解。

Quantitative proteomics reveals new insights into erythrocyte invasion by Plasmodium falciparum.

机构信息

School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.

出版信息

Mol Cell Proteomics. 2012 Feb;11(2):M111.010645. doi: 10.1074/mcp.M111.010645. Epub 2011 Oct 24.

DOI:10.1074/mcp.M111.010645
PMID:22023809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3277754/
Abstract

Differential expression of ligands in the human malaria parasite Plasmodium falciparum enables it to recognize different receptors on the erythrocyte surface, thereby providing alternative invasion pathways. Switching of invasion from using sialated to nonsialated erythrocyte receptors has been linked to the transcriptional activation of a single parasite ligand. We have used quantitative proteomics to show that in addition to this single known change, there are a significant number of changes in the expression of merozoite proteins that are regulated independent of transcription during invasion pathway switching. These results demonstrate a so far unrecognized mechanism by which the malaria parasite is able to adapt to variations in the host cell environment by post-transcriptional regulation.

摘要

人疟原虫疟原虫中配体的差异表达使其能够识别红细胞表面的不同受体，从而提供替代的入侵途径。从使用唾液酸化的红细胞受体到非唾液酸化的红细胞受体的入侵转换已被证明与单一寄生虫配体的转录激活有关。我们已经使用定量蛋白质组学表明，除了这种单一的已知变化外，在入侵途径转换过程中，有大量的裂殖子蛋白的表达变化是独立于转录的调节。这些结果表明，疟原虫通过转录后调控来适应宿主细胞环境变化的一种迄今尚未被认识的机制。