Arthritis & Osteoporosis Consultants of the Carolinas, 1918 Randolph Road, Suite 600, Charlotte, NC 28207, USA.
Rheum Dis Clin North Am. 2011 Aug;37(3):323-36, v. doi: 10.1016/j.rdc.2011.07.007.
Although a variety of medications are effective for the treatment of postmenopausal osteoporosis, there is concern that long-term use may incur side effects. Consequently, some have proposed discontinuing or temporarily suspending treatment after a defined period of time. As the benefits of fracture risk reduction may recede during this "drug holiday", the clinician may be faced with deciding when to resume therapy (and with which agent) while avoiding the possible cumulative risk of side effects. This article summarizes data regarding length of treatment and the effects of cessation of treatment on bone density, bone turnover markers, and fracture risk.
虽然有多种药物可有效治疗绝经后骨质疏松症，但人们担心长期使用可能会产生副作用。因此，一些人建议在规定的时间后停止或暂时停止治疗。由于骨折风险降低的益处可能会在这段“药物假期”期间消退，临床医生可能需要决定何时恢复治疗（使用哪种药物），同时避免可能的累积副作用风险。本文总结了关于治疗时间以及停止治疗对骨密度、骨转换标志物和骨折风险的影响的数据。
