术前吸入米力农可减轻体外循环心脏手术患者的炎症反应。
Preoperative inhalation of milrinone attenuates inflammation in patients undergoing cardiac surgery with cardiopulmonary bypass.
机构信息
Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
出版信息
Med Princ Pract. 2012;21(1):30-5. doi: 10.1159/000332411. Epub 2011 Oct 21.
OBJECTIVES
The purpose of this study was to evaluate the effect of preoperative inhalation of milrinone on cardiopulmonary bypass (CPB)-related inflammation.
SUBJECTS AND METHODS
A total of 30 patients undergoing cardiac surgery were recruited and randomized for preoperative inhalation of milrinone (Mil group) or normal saline (NS group), respectively. Each group had 15 patients. Their hemodynamic parameters were measured and blood samples were obtained longitudinally. The levels of serum interleukin (IL-6), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase (MMP)-9 were determined by ELISA.
RESULTS
The levels of serum IL-6, TNF-α, and MMP-9 significantly increased at the end of cardiac surgery and remained high for 24 h in both groups of patients. However, the levels of proinflammatory cytokines at the end of cardiac surgery in the Mil group of patients were significantly lower than those of the NS group of patients.
CONCLUSIONS
Our data indicated that preoperative inhalation of milrinone significantly mitigated CPB-related inflammation.
目的
本研究旨在评估术前米力农吸入对体外循环（CPB）相关炎症的影响。
对象与方法
共纳入 30 例行心脏手术的患者，并随机分为术前吸入米力农（Mil 组）或生理盐水（NS 组），每组各 15 例。测量患者的血流动力学参数，并进行纵向采血。通过 ELISA 法测定血清白细胞介素（IL-6）、肿瘤坏死因子-α（TNF-α）和基质金属蛋白酶（MMP-9）的水平。
结果
两组患者在心脏手术结束时血清 IL-6、TNF-α 和 MMP-9 水平显著升高，并在 24 h 内持续升高。然而，Mil 组患者心脏手术结束时的促炎细胞因子水平明显低于 NS 组。
结论
我们的数据表明，术前吸入米力农可显著减轻 CPB 相关炎症。
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