Department of Center for Disease Control and Prevention of Shaanxi Province, Xi'an, China.
Eur J Cancer Prev. 2011 Nov;20(6):445-52. doi: 10.1097/CEJ.0b013e328345f937.
Lung cancer is the second most common human malignant disease and the leading cause of cancer-related mortality worldwide. The effect of CYP1A1 IleVal polymorphism on susceptibility to lung cancer has been researched extensively over the last two decades. However, controversial results were obtained. To provide a more robust estimate of the effect, a meta-analysis was carried out. We systematically searched the PubMed database for studies published before August 2010, without language restriction. On the basis of our search criteria, a total of 32 studies (5126 patients and 6974 controls) were included in the meta-analysis. Overall, CYP1A1 IleVal polymorphism is associated with lung cancer risk (GG vs. AG+AA: odds ratio=1.61, 95% confidence interval: 1.19-2.17; GG vs. AA: odds ratio=1.70, 95% confidence interval: 1.23-2.35). Ethnic subgroup analyses showed that a significant association was found in Asians, but not in Africans, Caucasians, or other populations. In subgroup analyses by histology, the result is not reliable. In conclusion, this meta-analysis suggests that the CYP1A1 IleVal polymorphism might play a modest role in susceptibility to lung cancer, especially in Asians.
肺癌是人类第二大常见恶性疾病，也是全球癌症相关死亡的主要原因。在过去的二十年中，广泛研究了 CYP1A1 IleVal 多态性对肺癌易感性的影响。然而，得到的结果存在争议。为了提供更可靠的影响估计，进行了荟萃分析。我们系统地搜索了截至 2010 年 8 月之前发表的 PubMed 数据库，没有语言限制。根据我们的搜索标准，共有 32 项研究（5126 名患者和 6974 名对照）纳入荟萃分析。总体而言，CYP1A1 IleVal 多态性与肺癌风险相关（GG 与 AG+AA：比值比=1.61，95%置信区间：1.19-2.17；GG 与 AA：比值比=1.70，95%置信区间：1.23-2.35）。亚组分析显示，亚洲人群存在显著相关性，但非洲、高加索或其他人群则无。组织学亚组分析的结果不可靠。综上所述，该荟萃分析表明 CYP1A1 IleVal 多态性可能在肺癌易感性中起一定作用，尤其是在亚洲人群中。
