Liu Nan-Bo, Li Jun, Qi Jia-Feng, Zhang Zhen-Zhong, Wu Xu, Zhang Jun-Hua
Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland).
Department of Thoracic Surgery, Third Affiliated Hospital, Southern Medical University, Guangzhou, China (mainland).
Med Sci Monit. 2014 Dec 29;20:2817-23. doi: 10.12659/MSM.892050.
Although many epidemiology studies have investigated the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and their associations with lung cancer (LC), definite conclusions cannot be drawn. To clarify the effects of MTHFR polymorphisms on the risk of LC, we performed a meta-analysis in Chinese populations.
MATERIAL/METHODS: Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) until 16 February 2014. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations.
A total of 11 studies with 2487 LC cases and 3228 controls were included in this meta-analysis. Overall, no significant association was found between MTHFR C677T polymorphism and LC risk when all studies in Chinese populations were pooled into this meta-analysis. In subgroup analyses stratified by geographical location and source of controls, significantly increased risk was found in North China (T vs. C: OR=1.28, 95% CI: 1.14-1.44; TT vs. CC: OR=1.67, 95% CI: 1.33-2.10; TT + CT vs. CC, OR=1.39, 95% CI=1.15-1.69; TT vs. CC + CT: OR=1.46, 95% CI: 1.03-2.06) and in population-based studies (TT vs. CC: OR=1.37, 95% CI: 1.14-1.65; TT vs. CC + CT: OR=1.25, 95% CI: 1.07-1.45).
This meta-analysis provides evidence that MTHFR C677T polymorphism may contribute to LC development in North China. Studies with larger sample sizes and wider spectrum of populations are warranted to verify this finding.
尽管许多流行病学研究调查了亚甲基四氢叶酸还原酶（MTHFR）基因多态性及其与肺癌（LC）的关联，但仍无法得出明确结论。为阐明MTHFR基因多态性对肺癌风险的影响，我们对中国人群进行了一项荟萃分析。
材料/方法：通过检索PubMed、Springer Link、Ovid、中国万方数据知识服务平台、中国知网（CNKI）和中国生物医学文献数据库（CBM），收集截至2014年2月16日的相关研究。采用合并比值比（OR）和95%置信区间（CI）评估关联强度。
本荟萃分析共纳入11项研究，包括2487例肺癌病例和3228例对照。总体而言，将所有中国人群研究纳入荟萃分析后，未发现MTHFR C677T基因多态性与肺癌风险之间存在显著关联。在按地理位置和对照来源分层的亚组分析中，发现华北地区（T vs. C：OR = 1.28，95% CI：1.14 - 1.44；TT vs. CC：OR = 1.67，95% CI：1.33 - 2.10；TT + CT vs. CC，OR = 1.39，95% CI = 1.15 - 1.69；TT vs. CC + CT：OR = 1.46，95% CI：1.03 - 2.06）以及基于人群的研究（TT vs. CC：OR = 1.37，95% CI：1.14 - 1.65；TT vs. CC + CT：OR = 1.25，95% CI：1.07 - 1.45）中肺癌风险显著增加。
本荟萃分析提供了证据表明MTHFR C677T基因多态性可能与华北地区肺癌的发生有关。需要开展样本量更大、人群范围更广的研究来验证这一发现。
