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[肾移植问题(纪念苏联首次成功进行肾移植25周年)]

[Problem of kidney transplantation (on the 25th anniversary of the first successful transplantation of the kidney in the USSR)].

作者信息

Petrovskiĭ B V, Belorusov O S

出版信息

Khirurgiia (Mosk). 1990 May(5):3-7.

PMID:2202873
Abstract

The first successful transplantation of a kidney from an alive relative donor in the USSR was performed by B. V. Petrovsky at the All-Union Research Institute of Clinical and Experimental Surgery (now the All-Union Surgery Research Center, AMS, USSR) on April 15, 1965. In November, 1965 he transplanted a cadaver kidney for the first time with a good outcome. The Center possesses an experience with 987 kidney transplantations to date, among which 101 were related transplantations. The authors discuss the progress made in this field of surgery in a period of 25 years. The longest survival period among recipients with a functioning related kidney is 22 years and among those with a cadaver kidney, 19 years. With the use of Cy A 86% of transplanted related kidneys and 76% of cadaver kidneys function for 12 months or longer. The authors discuss the advantages of a new original method for transorganic oxygen preservation of a kidney suggested by G. A. Asoyan, instrumental-functional methods developed at the Center for appraising the hemodynamics of the transplanted kidney and diagnosis of the rejection crisis, cyclosporine nephrotoxicity, and progress in the techniques of kidney transplantation and immunosuppressive therapy. The authors believe that further improvement in the results of allogeneic kidney transplantation is well-grounded.

摘要

1965年4月15日,苏联全联盟临床与实验外科学研究所(现为苏联医学科学院全联盟外科研究中心)的B. V. 彼得罗夫斯基首次成功进行了活体亲属供肾移植手术。1965年11月,他首次进行了尸体肾移植,效果良好。该中心迄今已有987例肾移植经验,其中101例为亲属移植。作者们讨论了25年来该外科领域所取得的进展。有功能的亲属供肾受者的最长存活期为22年,尸体肾受者为19年。使用环孢素后,86%的亲属移植肾和76%的尸体肾有功能达12个月或更长时间。作者们讨论了G. A. 阿索扬提出的一种全新的肾器官内氧保存方法的优点、该中心为评估移植肾血流动力学及诊断排斥反应、环孢素肾毒性而研发的仪器功能方法,以及肾移植技术和免疫抑制疗法的进展。作者们认为,同种异体肾移植结果的进一步改善是有充分依据的。

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Khirurgiia (Mosk). 1990 May(5):3-7.
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