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炎症作为一种动物发育现象。

Inflammation as an animal development phenomenon.

作者信息

Ramos Gustavo Campos

机构信息

Department of Pharmacology, Biological Sciences Centre, Federal University of Santa Catarina, 88049-900 Florianópolis, SC, Brazil.

出版信息

Clin Dev Immunol. 2012;2012:983203. doi: 10.1155/2012/983203. Epub 2011 Oct 19.

Abstract

Inflammation is a term that has been used throughout history in different contexts; it may represent a simple collection of clinical symptoms for which drugs are developed, a disease mechanism, or even a defense mechanism against microbes validating Pasteur's studies on bacteriology and Darwin's proposed struggle for survival. Thus, an explanation of this term must also consider the scientific questions addressed. In this study, I propose that several of the inflammatory events typically described in immunological, pathological, and pharmacological contexts can also be perceived as mechanisms of animal development. Thus, by recognizing that the generation of an animal form, its conservation, and its regeneration after tissue damage are phenomena of the same nature, inflammation can be addressed through the approach of developmental biology, thereby acquiring a much neglected physiological counterpart.

摘要

炎症是一个在历史上被用于不同语境的术语;它可能代表着针对其研发药物的一组简单临床症状、一种疾病机制,甚至是一种针对微生物的防御机制,这证实了巴斯德的细菌学研究以及达尔文提出的生存斗争理论。因此,对这个术语的解释也必须考虑所涉及的科学问题。在本研究中,我提出在免疫学、病理学和药理学背景下通常描述的几种炎症事件也可被视为动物发育的机制。因此,通过认识到动物形态的形成、其维持以及组织损伤后的再生是具有相同性质的现象,炎症可以通过发育生物学的方法来研究,从而获得一个长期被忽视的生理对应物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa75/3199050/cf657e01c7dd/CDI2012-983203.001.jpg

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