Department of Surgery, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n., 28040, Madrid, Spain.
UCL Division of Medicine, Institute for Liver and Digestive Health, Rowland Hill Street, London, NW32PF, UK.
Inflamm Res. 2018 Feb;67(2):111-116. doi: 10.1007/s00011-017-1108-5. Epub 2017 Nov 3.
The inflammatory response expressed after wound healing would be the recapitulation of systemic extra-embryonic functions, which would focus on the interstitium of the injured tissue. In the injured tissue, mast cells, provided for a great functional heterogeneity, could play the leading role in the re-expression of extra-embryonic functions, i.e., coelomic-amniotic and trophoblastic-vitelline. Moreover, mast cells would favor the production of a gastrulation-like process, which in certain tissues and organs would induce the regeneration of the injured tissue. Therefore, the engraftment of mesenchymal stem cells and mast cells, both with an extra-embryonic regenerative phenotype, would achieve a blastema, from the repaired and regenerated injured tissue, rather than by fibrosis, which is commonly made through wound-healing.
在伤口愈合后表达的炎症反应将是全身胚外功能的重演，这将集中在受伤组织的间质上。在受伤组织中，提供了巨大功能异质性的肥大细胞可能在重新表达胚外功能方面发挥主导作用，即体腔-羊膜和滋养层-卵黄囊。此外，肥大细胞将有利于产生类似于原肠胚形成的过程，这在某些组织和器官中会诱导受伤组织的再生。因此，植入具有胚外再生表型的间充质干细胞和肥大细胞将从修复和再生的受伤组织中形成芽基，而不是通过通常通过伤口愈合形成的纤维化。
