Frayn K N, Coppack S W, Walsh P E, Butterworth H C, Humphreys S M, Pedrosa H C
Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, UK.
Metabolism. 1990 Sep;39(9):958-66. doi: 10.1016/0026-0495(90)90308-y.
Although excess ethanol consumption is often considered to lead to adiposity, the metabolic routes by which this might occur are not clear. We have investigated some metabolic consequences of acute ethanol ingestion by measuring arteriovenous differences across forearm muscle and subcutaneous adipose tissue for 6 hours after ingestion of 47.5 g ethanol, in seven normal subjects fasted overnight. The expected systemic effects of ethanol ingestion were observed: slight lowering of the plasma glucose concentration, depression of plasma nonesterified fatty acid (NEFA) concentrations, and elevation of the blood lactate/pyruvate and 3-hydroxybutyrate/acetoacetate ratios. There was a marked reduction in blood total ketone bodies in relation to plasma NEFA concentrations. However, the only major change observed in peripheral tissue metabolism was an increased uptake of acetate into forearm muscle, equivalent, in whole-body terms, to only 3% of the ethanol load. Adipose tissue appeared to show a reduced cytoplasmic state in that it exported an increased ratio of lactate to pyruvate after ethanol ingestion. However, this reduced state did not lead to increased fatty acid reesterification within adipose tissue. No mechanism was clearly identified whereby ethanol ingestion might lead to net deposition of triacylglycerol in adipose tissue.
尽管过量饮酒通常被认为会导致肥胖，但这种情况可能发生的代谢途径尚不清楚。我们通过测量七名过夜禁食的正常受试者摄入47.5克乙醇后6小时内前臂肌肉和皮下脂肪组织的动静脉差异，研究了急性摄入乙醇的一些代谢后果。观察到了摄入乙醇后预期的全身效应：血浆葡萄糖浓度略有降低、血浆非酯化脂肪酸（NEFA）浓度降低、血乳酸/丙酮酸和3-羟基丁酸/乙酰乙酸比值升高。与血浆NEFA浓度相比，血中总酮体显著减少。然而，在周围组织代谢中观察到的唯一主要变化是前臂肌肉对乙酸盐的摄取增加，从全身来看，这仅相当于乙醇负荷的3%。乙醇摄入后，脂肪组织输出的乳酸与丙酮酸的比值增加，似乎显示出细胞质状态降低。然而，这种降低状态并未导致脂肪组织内脂肪酸再酯化增加。没有明确确定乙醇摄入可能导致脂肪组织中甘油三酯净沉积的机制。
