Quinn Joseph F, Harris Christopher, Kaye Jeffrey A, Lind Babett, Carter Raina, Anekonda Thimmappa, Ralle Martina
Department of Neurology, Portland VA Medical Center and Oregon Health & Science University, Portland, OR 97239, USA.
Int J Alzheimers Dis. 2011;2011:150916. doi: 10.4061/2011/150916. Epub 2011 Oct 19.
The effect of gender on systemic and brain levels of copper is relatively understudied. We examined gender effects in mice and human subjects. We observed a trend to higher serum copper levels in female compared to male LaFerla "triple transgenic" (1399 ± 233 versus 804 ± 436 ng/mL, P = 0.06) mice, and significantly higher brain copper levels in female- versus male wild-type mice (5.2 ± 0.2 versus 4.18 ± 0.3 ng/mg wet wt, P = 0.03). Plasma copper was significantly correlated with brain copper in mice (R2 = 0.218; P = 0.038). Among human subjects with AD, both plasma copper (1284 ± 118 versus 853 ± 81 ng/mL, P = 0.005) and cerebrospinal fluid copper (12.8 ± 1 versus 10.4 ± 0.7 ng/mL, P = 0.01) were elevated in women compared to men. Among healthy control subjects, plasma copper (1008 ± 51 versus 836 ± 41 ng/mL; P = 0.01) was higher in women than in men, but there was no difference in cerebrospinal fluid copper. We conclude that gender differences in copper status may influence copper-mediated pathological events in the brain.
性别对全身和大脑铜水平的影响相对研究较少。我们在小鼠和人类受试者中研究了性别影响。我们观察到，与雄性“三重转基因”（LaFerla）小鼠相比，雌性小鼠血清铜水平有升高趋势（1399±233对804±436 ng/mL，P = 0.06），并且雌性野生型小鼠的脑铜水平显著高于雄性（5.2±0.2对4.18±0.3 ng/mg湿重，P = 0.03）。小鼠血浆铜与脑铜显著相关（R2 = 0.218；P = 0.038）。在患有阿尔茨海默病的人类受试者中，女性的血浆铜（1284±118对853±81 ng/mL，P = 0.005）和脑脊液铜（12.8±1对10.4±0.7 ng/mL，P = 0.01）均高于男性。在健康对照受试者中，女性的血浆铜（1008±51对836±41 ng/mL；P = 0.01）高于男性，但脑脊液铜无差异。我们得出结论，铜状态的性别差异可能会影响大脑中铜介导的病理事件。
