School of Medicine, University of St Andrews, Medical and Biological Sciences Building, St Andrews, Fife, UK.
Scottish Trace Element and Micronutrient Diagnostic and Reference Laboratory, Department of Biochemistry, NHS Greater Glasgow and Clyde, Glasgow, UK.
Biometals. 2023 Apr;36(2):241-253. doi: 10.1007/s10534-022-00368-7. Epub 2022 Feb 9.
Obesity enhances the risk of type-2 diabetes, cardiovascular disease and inflammatory conditions and often leads to metal dyshomeostasis, which contributes to the negative health aspects associated with the disease. In severe cases, bariatric surgery can be recommended to achieve sustained weight loss and improvement in health. Here, magnesium, zinc, copper and selenium concentrations were examined in 24 obese patients (7 males; 17 females) before and 9 months after undergoing Roux-en-Y gastric bypass surgery. All patients lost weight over this period, with the mean BMI reducing from 51.2±7.1 kg/m to 37.2±5.5 kg/m. Moreover, whole-blood glycated haemoglobin (HbA1c), as a marker of average glycaemia, was also measured and a correlative analysis of this parameter with metal concentrations performed. Significant alterations in the plasma concentrations of magnesium, zinc (both increased by 13.2% and 25.2% respectively) and copper (decreased by 7.9%) were observed over this period (plasma selenium concentration was unchanged), with BMI values correlating with plasma magnesium (p = 0.004) and zinc (p = 0.022) concentrations. At 9 months post-surgery, an increase in mean zinc/copper ratio was observed (0.86±0.29 compared to 0.63±0.14 pre-surgery). Comparison of whole-blood HbA1c concentrations pre- and post-surgery revealed a reduction from 6.50±1.28% pre-surgery to 5.51±0.49% post-surgery. Differences in plasma HbA1c and magnesium at either pre- and post-surgery correlated significantly, as did HbA1c and magnesium levels when pre- and post-surgery values were analysed together. Collectively, this work reveals that bariatric surgery, in conjunction with lifestyle/dietary changes, lead to improvements in the nutritional status of magnesium, zinc and copper. Furthermore, the observed improvements in magnesium and zinc were associated with weight loss and in the case of magnesium, to better glycaemic control.
肥胖会增加 2 型糖尿病、心血管疾病和炎症的风险，并且常常导致金属代谢失衡，这对与疾病相关的负面健康方面有影响。在严重的情况下，可能会推荐进行减肥手术以实现持续的体重减轻和改善健康状况。在这里，在接受 Roux-en-Y 胃旁路手术后的 9 个月内，检查了 24 名肥胖患者（7 名男性；17 名女性）的镁、锌、铜和硒浓度。在此期间，所有患者的体重都减轻了，平均 BMI 从 51.2±7.1kg/m 降低到 37.2±5.5kg/m。此外，还测量了全血糖化血红蛋白（HbA1c）作为平均血糖的标志物，并对该参数与金属浓度进行了相关分析。在此期间，观察到镁、锌（分别增加了 13.2%和 25.2%）和铜（减少了 7.9%）的血浆浓度发生了显著变化（血浆硒浓度保持不变），BMI 值与血浆镁（p=0.004）和锌（p=0.022）浓度相关。手术后 9 个月，观察到平均锌/铜比值增加（0.86±0.29 比手术前的 0.63±0.14）。手术前后全血 HbA1c 浓度的比较显示，从手术前的 6.50±1.28%降低到手术后的 5.51±0.49%。手术前后血浆 HbA1c 和镁的差异显著相关，并且手术前后分析的 HbA1c 和镁水平也显著相关。总的来说，这项工作表明，减肥手术与生活方式/饮食改变相结合，导致镁、锌和铜的营养状况得到改善。此外，镁和锌的观察到的改善与体重减轻有关，而对于镁，与更好的血糖控制有关。
