Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Clin Transl Sci. 2011 Oct;4(5):323-7. doi: 10.1111/j.1752-8062.2011.00314.x.
Obesity disproportionately affects Latina women. Common genetic variants are convincingly associated with body mass index (BMI) and may be used to create genetic risk scores (GRS) for obesity that could define genetically influenced forms of obesity and alter response to clinical trial interventions. The objective of this study was (1) to identify the frequency and effect size of common obesity genetic variants in Latina women; (2) to determine the clinical utility of a GRS for obesity with Latina women participating in a community-based clinical trial. DNA from 85 Latina women was genotyped for eight genetic variants previously associated with BMI in Caucasians, but not yet assessed in Latina populations. The main outcome measure was the correlation of GRS (sum of eight risk alleles) with BMI, waist circumference, and percent body fat. A majority (83%) of participants had a BMI ≥25. Frequency of loci near FTO, MC4R, and GNPDA2 were lower in Latinas than Caucasians. Association of each locus with BMI was lower in Latinas compared to Caucasians with no significant correlations with BMI. We conclude that an eight locus GRS has no clinical utility for explaining obesity or predicting response to intervention in Latina women participating in a clinical trial.
肥胖症在拉丁裔女性中不成比例地高发。常见的遗传变异与体重指数（BMI）有明显关联，这些变异可用于构建肥胖遗传风险评分（GRS），以确定受遗传影响的肥胖类型，并改变对临床试验干预的反应。本研究的目的是：（1）确定拉丁裔女性常见肥胖遗传变异的频率和效应大小；（2）确定在参与社区临床研究的拉丁裔女性中，肥胖 GRS 的临床实用性。对 85 名拉丁裔女性的 DNA 进行了 8 种先前与白种人 BMI 相关但尚未在拉丁裔人群中评估的遗传变异的基因分型。主要观察指标是 GRS（8 个风险等位基因的总和）与 BMI、腰围和体脂百分比的相关性。大多数（83%）参与者的 BMI≥25。与白种人相比，FTO、MC4R 和 GNPDA2 附近的位点频率在拉丁裔中较低。与白种人相比，每个位点与 BMI 的关联较低，与 BMI 无显著相关性。我们得出结论，一个包含 8 个基因座的 GRS 对于解释肥胖症或预测参与临床试验的拉丁裔女性对干预的反应没有临床实用性。
